HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington’s disease pathogenesis

• Shiyu Xu ,

  Contributed equally to this work with: Shiyu Xu, Gang Li

  Roles Data curation, Methodology

  Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  ⨯
• Gang Li ,

  Contributed equally to this work with: Shiyu Xu, Gang Li

  Roles Data curation, Methodology

  Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  ⨯
• Xin Ye,

  Roles Data curation, Methodology

  Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  ⨯
• Dongsheng Chen,

  Roles Data curation, Methodology

  Current Address: The College of Life Sciences, Anhui Normal University, Wuhu, Anhui, People’s Republic of China

  Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  ⨯
• Zhihua Chen,

  Roles Data curation, Methodology

  Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  ⨯
• Zhen Xu,

  Roles Data curation, Methodology

  Current Address: Department of Neurosurgery, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  ⨯
• Moretti Daniele,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Translational and Discovery Research, IRBM SpA, Pomezia (RM), Italy

  ⨯
• Sara Tambone,

  Roles Data curation

  Affiliation Department of Translational and Discovery Research, IRBM SpA, Pomezia (RM), Italy

  ⨯
• Alessandra Ceccacci,

  Roles Data curation

  Affiliation Department of Translational and Discovery Research, IRBM SpA, Pomezia (RM), Italy

  ⨯
• Licia Tomei,

  Roles Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Translational and Discovery Research, IRBM SpA, Pomezia (RM), Italy

  https://orcid.org/0000-0001-6396-6601

  ⨯
• Lili Ye,

  Roles Data curation

  Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  ⨯
• Yue Yu,

  Roles Data curation

  Affiliations The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America, Programs in Genetics and Epigenetics and Neuroscience, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, United States of America

  https://orcid.org/0000-0002-0860-6643

  ⨯
• Amanda Solbach,

  Roles Data curation

  Affiliations The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America, Programs in Genetics and Epigenetics and Neuroscience, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, United States of America

  https://orcid.org/0000-0001-8130-8514

  ⨯
• Stephen M. Farmer,

  Roles Data curation

  Affiliations The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America, Program in Biochemistry and Cell Biology, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, United States of America

  ⨯
• Erin Furr Stimming,

  Roles Formal analysis

  Affiliation Department of Neurology, HDSA Center of Excellence, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

  ⨯
• George McAllister,

  Roles Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation CHDI Management/CHDI Foundation, 350 Seventh Ave, New York, New York, United States of America

  ⨯
• Deanna M. Marchionini,

  Roles Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation CHDI Management/CHDI Foundation, 350 Seventh Ave, New York, New York, United States of America

  https://orcid.org/0000-0003-2071-1064

  ⨯
•  [ ... ],
• Sheng Zhang

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Sheng.Zhang@uth.tmc.edu

  Affiliations The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America, Programs in Genetics and Epigenetics and Neuroscience, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, United States of America, Department of Neurobiology and Anatomy, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

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