Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans

• Sijie Wu ,

  Contributed equally to this work with: Sijie Wu, Manfei Zhang, Xinzhou Yang

  Roles Data curation, Formal analysis, Writing – original draft

  Affiliation CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

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• Manfei Zhang ,

  Contributed equally to this work with: Sijie Wu, Manfei Zhang, Xinzhou Yang

  Roles Data curation, Formal analysis, Writing – original draft

  Affiliations CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, Human Phenome Institute, Fudan University, 825 Zhangheng Road, Shanghai, China

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• Xinzhou Yang ,

  Contributed equally to this work with: Sijie Wu, Manfei Zhang, Xinzhou Yang

  Roles Data curation, Formal analysis

  Affiliations CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, SIBS (Institute of Health Sciences) Changzheng Hospital Joint Center for Translational Research, Institutes for Translational Research (CAS-SMMU), Shanghai, China

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• Fuduan Peng,

  Roles Data curation, Formal analysis

  Affiliation Key laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

  http://orcid.org/0000-0003-4068-530X

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• Juan Zhang,

  Roles Data curation

  Affiliation Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China

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• Jingze Tan,

  Roles Data curation

  Affiliation State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China

  ⨯
• Yajun Yang,

  Roles Data curation

  Affiliations State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China

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• Lina Wang,

  Roles Formal analysis

  Affiliation CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Yanan Hu,

  Roles Formal analysis

  Affiliation CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Qianqian Peng,

  Roles Data curation

  Affiliation CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Jinxi Li,

  Roles Data curation

  Affiliation CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

  ⨯
• Yu Liu,

  Roles Data curation

  Affiliation CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

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• Yaqun Guan,

  Roles Data curation

  Affiliation Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi, China

  ⨯
• Chen Chen,

  Roles Data curation

  Affiliation Department of Stomatology, Chang Zheng Hospital, Second Military Medical University, Shanghai, China

  ⨯
• Merel A. Hamer,

  Roles Data curation

  Affiliation Department of Dermatology, Erasmus MC University Medical Center Rotterdam, CA Rotterdam, The Netherlands

  ⨯
• Tamar Nijsten,

  Roles Resources

  Affiliation Department of Dermatology, Erasmus MC University Medical Center Rotterdam, CA Rotterdam, The Netherlands

  ⨯
• Changqing Zeng,

  Roles Data curation, Funding acquisition

  Affiliation Key laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

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• Kaustubh Adhikari,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, United Kingdom

  ⨯
• Carla Gallo,

  Roles Data curation

  Affiliation Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru

  ⨯
• Giovanni Poletti,

  Roles Funding acquisition, Resources

  Affiliation Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru

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• Lavinia Schuler-Faccini,

  Roles Data curation, Resources

  Affiliation Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre Brasil

  ⨯
• Maria-Cátira Bortolini,

  Roles Resources

  Affiliation Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre Brasil

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• Samuel Canizales-Quinteros,

  Roles Resources

  Affiliation Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica, México City, México

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• Francisco Rothhammer,

  Roles Resources

  Affiliation Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Chile

  ⨯
• Gabriel Bedoya,

  Roles Resources

  Affiliation Laboratorio de Genética Molecular (GENMOL), Universidad de Antioquia, Medellín, Colombia

  http://orcid.org/0000-0001-7281-3981

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• Rolando González-José,

  Roles Funding acquisition, Resources

  Affiliation Instituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, CONICET, Puerto Madryn, Argentina

  ⨯
• Hui Li,

  Roles Resources

  Affiliation State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China

  ⨯
• Jean Krutmann,

  Roles Resources

  Affiliation IUF-Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany

  ⨯
• Fan Liu,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations Key laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, CA Rotterdam, The Netherlands

  http://orcid.org/0000-0001-9241-8161

  ⨯
• Manfred Kayser,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliation Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, CA Rotterdam, The Netherlands

  ⨯
• Andres Ruiz-Linares,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, United Kingdom

  ⨯
• Kun Tang,

  Roles Data curation, Funding acquisition, Resources

  Affiliations CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China

  ⨯
• Shuhua Xu,

  Roles Data curation, Funding acquisition, Resources

  Affiliations CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, School of Life Science and Technology, ShanghaiTech University, Shanghai, China, Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming China

  http://orcid.org/0000-0002-1975-1002

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• Liang Zhang ,

  Roles Conceptualization, Data curation, Funding acquisition, Resources, Supervision, Writing – original draft

  * E-mail: zhangliang01@sibs.ac.cn (LZ); lijin@fudan.edu.cn (LJ); wangsijia@picb.ac.cn (SW)

  Affiliations CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, SIBS (Institute of Health Sciences) Changzheng Hospital Joint Center for Translational Research, Institutes for Translational Research (CAS-SMMU), Shanghai, China

  ⨯
• Li Jin ,

  Roles Conceptualization, Data curation, Funding acquisition, Resources

  * E-mail: zhangliang01@sibs.ac.cn (LZ); lijin@fudan.edu.cn (LJ); wangsijia@picb.ac.cn (SW)

  Affiliations CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, Human Phenome Institute, Fudan University, 825 Zhangheng Road, Shanghai, China

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•  [ ... ],
• Sijia Wang

  Roles Conceptualization, Data curation, Funding acquisition, Resources, Supervision, Writing – original draft

  * E-mail: zhangliang01@sibs.ac.cn (LZ); lijin@fudan.edu.cn (LJ); wangsijia@picb.ac.cn (SW)

  Affiliations CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China, Human Phenome Institute, Fudan University, 825 Zhangheng Road, Shanghai, China, Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming China

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