Absence of Maternal Methylation in Biparental Hydatidiform Moles from Women with NLRP7 Maternal-Effect Mutations Reveals Widespread Placenta-Specific Imprinting

• Marta Sanchez-Delgado,

  Affiliation Imprinting and Cancer Group, Cancer Epigenetic and Biology Program, Institut d’Investigació Biomedica de Bellvitge, Hospital Duran i Reynals, Barcelona, Spain

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• Alejandro Martin-Trujillo,

  Affiliation Imprinting and Cancer Group, Cancer Epigenetic and Biology Program, Institut d’Investigació Biomedica de Bellvitge, Hospital Duran i Reynals, Barcelona, Spain

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• Chiharu Tayama,

  Affiliation Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan

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• Enrique Vidal,

  Affiliation Cancer Epigenetics Group, Cancer Epigenetic and Biology Program, Institut d’Investigació Biomedica de Bellvitge, Hospital Duran i Reynals, Barcelona, Spain

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• Manel Esteller,

  Affiliations Cancer Epigenetics Group, Cancer Epigenetic and Biology Program, Institut d’Investigació Biomedica de Bellvitge, Hospital Duran i Reynals, Barcelona, Spain, Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain, Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Spain

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• Isabel Iglesias-Platas,

  Affiliation Servicio de Neonatología, Hospital Sant Joan de Déu, Fundació Sant Joan de Déu, Barcelona, Spain

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• Nandita Deo,

  Affiliation Whipps Cross University Hospital, Barts Health NHS Trust, Leytonstone, London, United Kingdom

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• Olivia Barney,

  Affiliation Leicester Royal Infirmary, Leicester, United Kingdom

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• Ken Maclean,

  Affiliation Primary Care Genetics, Sydney, Australia

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• Kenichiro Hata,

  Affiliation Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan

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• Kazuhiko Nakabayashi,

  Affiliation Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo, Japan

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• Rosemary Fisher,

  Affiliations Imperial Centre for Translational and Experimental Medicine, Imperial College London, London, United Kingdom, Trophoblastic Tumour Screening and Treatment Centre, Department of Oncology, Imperial College London, London, United Kingdom

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• David Monk

  * E-mail: dmonk@idibell.cat

  Affiliation Imprinting and Cancer Group, Cancer Epigenetic and Biology Program, Institut d’Investigació Biomedica de Bellvitge, Hospital Duran i Reynals, Barcelona, Spain

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