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Open Access
Peer-reviewed
Research Article
Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model
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Shamim H. Rahman ,
Contributed equally to this work with: Shamim H. Rahman, Johannes Kuehle
Affiliations Institute for Cell and Gene Therapy, University Medical Center Freiburg, Freiburg, Germany, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany, Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany
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Johannes Kuehle ,
Contributed equally to this work with: Shamim H. Rahman, Johannes Kuehle
Affiliation Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany
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Christian Reimann,
Affiliations Institute for Cell and Gene Therapy, University Medical Center Freiburg, Freiburg, Germany, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
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Tafadzwa Mlambo,
Affiliations Institute for Cell and Gene Therapy, University Medical Center Freiburg, Freiburg, Germany, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany, Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany
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Jamal Alzubi,
Affiliations Institute for Cell and Gene Therapy, University Medical Center Freiburg, Freiburg, Germany, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany, Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany
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Morgan L. Maeder,
Affiliations Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
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Heimo Riedel,
Affiliations Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany, Department of Biochemistry and Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, United States of America
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Paul Fisch,
Affiliation Institute of Pathology, University Medical Center Freiburg, Freiburg, Germany
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Tobias Cantz,
Affiliation Translational Hepatology and Stem Cell Biology, REBIRTH cluster of excellence, Hannover Medical School, Hannover, Germany
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Cornelia Rudolph,
Affiliation Institute for Cellular and Molecular Pathology, Hannover Medical School, Hannover, Germany
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Claudio Mussolino,
Affiliations Institute for Cell and Gene Therapy, University Medical Center Freiburg, Freiburg, Germany, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
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J. Keith Joung,
Affiliations Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
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Axel Schambach ,
* E-mail: Schambach.Axel@mh-hannover.de (AS); Toni.Cathomen@uniklinik-freiburg.de (TC)
¶‡ AS and TC also contributed equally to this work.
Affiliation Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany
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Toni Cathomen
* E-mail: Schambach.Axel@mh-hannover.de (AS); Toni.Cathomen@uniklinik-freiburg.de (TC)
¶‡ AS and TC also contributed equally to this work.
Affiliations Institute for Cell and Gene Therapy, University Medical Center Freiburg, Freiburg, Germany, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany, Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany
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Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model
- Shamim H. Rahman,
- Johannes Kuehle,
- Christian Reimann,
- Tafadzwa Mlambo,
- Jamal Alzubi,
- Morgan L. Maeder,
- Heimo Riedel,
- Paul Fisch,
- Tobias Cantz,
- Cornelia Rudolph
- Published: May 22, 2015
- https://doi.org/10.1371/journal.pgen.1005239