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Open Access
Peer-reviewed
Research Article
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
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Momoko Horikoshi ,
Contributed equally to this work with: Momoko Horikoshi, Reedik Mӓgi
* E-mail: momoko@well.ox.ac.uk
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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Reedik Mӓgi ,
Contributed equally to this work with: Momoko Horikoshi, Reedik Mӓgi
Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia
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Martijn van de Bunt,
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
⨯ -
Ida Surakka,
Affiliations Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland
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Antti-Pekka Sarin,
Affiliations Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland
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Anubha Mahajan,
Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
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Letizia Marullo,
Affiliation Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
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Gudmar Thorleifsson,
Affiliation deCode Genetic - Amgen Inc, Reykjavik, Iceland
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Sara Hӓgg,
Affiliations Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Medical Sciences, Molecular Epidemiology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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Jouke-Jan Hottenga,
Affiliation Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
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Claes Ladenvall,
Affiliation Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden
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Janina S. Ried,
Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
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Thomas W. Winkler,
Affiliation Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany
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Sara M. Willems,
Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
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Natalia Pervjakova,
Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia
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Tõnu Esko,
Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Division of Endocrinology and Center for Basic and Translational Obesity Research, Children’s Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
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Marian Beekman,
Affiliations Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
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Christopher P. Nelson,
Affiliations Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, National Institute for Health Research Leicester Cardiovascular Disease Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
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Christina Willenborg,
Affiliations Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany, DZHK German Center for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany
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Steven Wiltshire †,
† Deceased.
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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Teresa Ferreira,
Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
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Juan Fernandez,
Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
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Kyle J. Gaulton,
Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
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Valgerdur Steinthorsdottir,
Affiliation deCode Genetic - Amgen Inc, Reykjavik, Iceland
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Anders Hamsten,
Affiliation Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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Patrik K. E. Magnusson,
Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Gonneke Willemsen,
Affiliation Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
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Yuri Milaneschi,
Affiliation Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
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Neil R. Robertson,
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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Christopher J. Groves,
Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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Amanda J. Bennett,
Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
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Terho Lehtimӓki,
Affiliation Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland
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Jorma S. Viikari,
Affiliation Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland
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Johan Rung,
Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, United Kingdom
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Valeriya Lyssenko,
Affiliations Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden, Steno Diabetes Center A/S, Gentofte, Denmark
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Markus Perola,
Affiliations Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland
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Iris M. Heid,
Affiliation Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany
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Christian Herder,
Affiliations Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany
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Harald Grallert,
Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
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Martina Müller-Nurasyid,
Affiliations Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
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Michael Roden,
Affiliations Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany, Department of Endocrinology and Diabetology, University Hospital Düsseldorf, Düsseldorf, Germany
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Elina Hypponen,
Affiliations School of Population Health, University of South Australia, Adelaide, Australia, Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, United Kingdom
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Aaron Isaacs,
Affiliations Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Center for Medical Systems Biology, Leiden, The Netherlands
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Elisabeth M. van Leeuwen,
Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
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Lennart C. Karssen,
Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
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Evelin Mihailov,
Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia
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Jeanine J. Houwing-Duistermaat,
Affiliation Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
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Anton J. M. de Craen,
Affiliations Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
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Joris Deelen,
Affiliations Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
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Aki S. Havulinna,
Affiliation Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland
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Matthew Blades,
Affiliation Bioinformatics and Biostatistics Support Hub (B/BASH), University of Leicester, Leicester, United Kingdom
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Christian Hengstenberg,
Affiliations Deutsches Herzzentrum München, Technische Universität München, Munich, Germany, DZHK German Center for Cardiovascular Research, Partner Site Munich, Munich, Germany
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Jeanette Erdmann,
Affiliations Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany, DZHK German Center for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany
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Heribert Schunkert,
Affiliations Deutsches Herzzentrum München, Technische Universität München, Munich, Germany, DZHK German Center for Cardiovascular Research, Partner Site Munich, Munich, Germany
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Jaakko Kaprio,
Affiliations Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland, The Department of Public Health, University of Helsinki, Helsinki, Finland
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Martin D. Tobin,
Affiliations Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
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Nilesh J. Samani,
Affiliations Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom, National Institute for Health Research Leicester Cardiovascular Disease Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom
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Lars Lind,
Affiliation Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset, Uppsala, Sweden
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Veikko Salomaa,
Affiliation Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland
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Cecilia M. Lindgren,
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
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P. Eline Slagboom,
Affiliations Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
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Andres Metspalu,
Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
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Cornelia M. van Duijn,
Affiliations Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Center for Medical Systems Biology, Leiden, The Netherlands
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Johan G. Eriksson,
Affiliations Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Folkhalsan Research Center, Helsinki, Finland, Vasa Central Hospital, Vasa, Finland, Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
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Annette Peters,
Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
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Christian Gieger,
Affiliations Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
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Antti Jula,
Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland
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Leif Groop,
Affiliations Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden
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Olli T. Raitakari,
Affiliations Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland
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Chris Power,
Affiliation Centre for Paediatric Epidemiology and Biostatistics, University College London Institute of Child Health, London, United Kingdom
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Brenda W. J. H. Penninx,
Affiliation Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
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Eco de Geus,
Affiliations Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands, EMGO Institute for Health and Care Research, VU University & VU University Medical Center, Amsterdam, The Netherlands
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Johannes H. Smit,
Affiliation Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
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Dorret I. Boomsma,
Affiliation Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
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Nancy L. Pedersen,
Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Erik Ingelsson,
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Medical Sciences, Molecular Epidemiology, and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
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Unnur Thorsteinsdottir,
Affiliations deCode Genetic - Amgen Inc, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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Kari Stefansson,
Affiliations deCode Genetic - Amgen Inc, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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Samuli Ripatti ,
¶‡ These authors jointly directed this work.
Affiliations Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland, The Department of Public Health, University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
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Inga Prokopenko ,
¶‡ These authors jointly directed this work.
Affiliation Deparment of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom
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Mark I. McCarthy ,
¶‡ These authors jointly directed this work.
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom
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Andrew P. Morris ,
¶‡ These authors jointly directed this work.
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Estonian Genome Center, University of Tartu, Tartu, Estonia, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
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Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation
- Momoko Horikoshi,
- Reedik Mӓgi,
- Martijn van de Bunt,
- Ida Surakka,
- Antti-Pekka Sarin,
- Anubha Mahajan,
- Letizia Marullo,
- Gudmar Thorleifsson,
- Sara Hӓgg,
- Jouke-Jan Hottenga
- Published: July 1, 2015
- https://doi.org/10.1371/journal.pgen.1005230