The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation

Jordi Solana; Chiara Gamberi; Yuliana Mihaylova; Stefanie Grosswendt; Chen Chen; Paul Lasko; Nikolaus Rajewsky; A. Aziz Aboobaker

doi:10.1371/journal.pgen.1004003

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Peer-reviewed

Research Article

The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation

Jordi Solana ,

* E-mail: Jordi.Solana@mdc-berlin.de (JS); Aziz.Aboobaker@zoo.ox.ac.uk (AAA)

Affiliations Centre for Genetics and Genomics, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom, Systems Biology of Gene Regulatory Elements, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Chiara Gamberi,

Current address: Institut de Recherches Cliniques de Montreal, Montréal, Québec, Canada.

Affiliations Department of Biology, McGill University, Montréal, Québec, Canada, Department of Biology, Concordia University, Montreal, Québec, Canada
⨯
Yuliana Mihaylova,

Affiliations Centre for Genetics and Genomics, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom, Department of Zoology, University of Oxford, Oxford, United Kingdom
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Stefanie Grosswendt,

Affiliation Systems Biology of Gene Regulatory Elements, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Chen Chen,

Affiliation Centre for Genetics and Genomics, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom
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Paul Lasko,

Affiliation Department of Biology, McGill University, Montréal, Québec, Canada
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Nikolaus Rajewsky,

Affiliation Systems Biology of Gene Regulatory Elements, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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A. Aziz Aboobaker

* E-mail: Jordi.Solana@mdc-berlin.de (JS); Aziz.Aboobaker@zoo.ox.ac.uk (AAA)

Affiliations Centre for Genetics and Genomics, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom, Department of Zoology, University of Oxford, Oxford, United Kingdom
⨯

The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation

Jordi Solana,
Chiara Gamberi,
Yuliana Mihaylova,
Stefanie Grosswendt,
Chen Chen,
Paul Lasko,
Nikolaus Rajewsky,
A. Aziz Aboobaker

Published: December 19, 2013
https://doi.org/10.1371/journal.pgen.1004003

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RNA interference
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Messenger RNA
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Stem cells
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Cell differentiation
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Planarians
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Gene expression
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