Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

Alfred Amambua-Ngwa; Kevin K. A. Tetteh; Magnus Manske; Natalia Gomez-Escobar; Lindsay B. Stewart; M. Elizabeth Deerhake; Ian H. Cheeseman; Christopher I. Newbold; Anthony A. Holder; Ellen Knuepfer; Omar Janha; Muminatou Jallow; Susana Campino; Bronwyn MacInnis; Dominic P. Kwiatkowski; David J. Conway

doi:10.1371/journal.pgen.1002992

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Peer-reviewed

Research Article

Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

Alfred Amambua-Ngwa,

Affiliation Medical Research Council Unit, Fajara, Banjul, The Gambia
⨯
Kevin K. A. Tetteh,

Affiliation Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Magnus Manske,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Natalia Gomez-Escobar,

Affiliation Medical Research Council Unit, Fajara, Banjul, The Gambia
⨯
Lindsay B. Stewart,

Affiliation Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
M. Elizabeth Deerhake,

Affiliation Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Ian H. Cheeseman,

Affiliations Medical Research Council Unit, Fajara, Banjul, The Gambia, Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Christopher I. Newbold,

Affiliation Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⨯
Anthony A. Holder,

Affiliation Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
⨯
Ellen Knuepfer,

Affiliation Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom
⨯
Omar Janha,

Affiliation Medical Research Council Unit, Fajara, Banjul, The Gambia
⨯
Muminatou Jallow,

Affiliation Medical Research Council Unit, Fajara, Banjul, The Gambia
⨯
Susana Campino,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Bronwyn MacInnis,

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Dominic P. Kwiatkowski,

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
⨯
[ ... ],
David J. Conway

* E-mail: david.conway@lshtm.ac.uk

Affiliations Medical Research Council Unit, Fajara, Banjul, The Gambia, Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
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Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

Alfred Amambua-Ngwa,
Kevin K. A. Tetteh,
Magnus Manske,
Natalia Gomez-Escobar,
Lindsay B. Stewart,
M. Elizabeth Deerhake,
Ian H. Cheeseman,
Christopher I. Newbold,
Anthony A. Holder,
Ellen Knuepfer

Published: November 1, 2012
https://doi.org/10.1371/journal.pgen.1002992

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Natural selection
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Plasmodium
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Malarial parasites
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Single nucleotide polymorphisms
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Genomics
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Gene expression
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Malaria
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