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Open Access
Peer-reviewed
Research Article
Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis
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Phuoc T. Tran ,
Contributed equally to this work with: Phuoc T. Tran, Emelyn H. Shroff, Timothy F. Burns
* E-mail: tranp@jhmi.edu (PTT); dfelsher@stanford.edu (DWF)
Affiliations Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America
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Emelyn H. Shroff ,
Contributed equally to this work with: Phuoc T. Tran, Emelyn H. Shroff, Timothy F. Burns
Affiliation Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, Stanford, California, United States of America
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Timothy F. Burns ,
Contributed equally to this work with: Phuoc T. Tran, Emelyn H. Shroff, Timothy F. Burns
Affiliation Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America
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Saravanan Thiyagarajan,
Affiliation Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America
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Sandhya T. Das,
Affiliation Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America
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Tahera Zabuawala,
Affiliation Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, Stanford, California, United States of America
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Joy Chen,
Affiliation Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, Stanford, California, United States of America
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Yoon-Jae Cho,
Affiliation Department of Neurology, Children's Hospital Boston, Boston, Massachusetts, United States of America
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Richard Luong,
Affiliation Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California, United States of America
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Pablo Tamayo,
Affiliation Broad Institute, Cambridge, Massachusetts, United States of America
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Tarek Salih,
Affiliation Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America
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Khaled Aziz,
Affiliation Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America
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Stacey J. Adam,
Affiliation Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, Stanford, California, United States of America
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Silvestre Vicent,
Affiliation Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America
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Carsten H. Nielsen,
Affiliation Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America
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Nadia Withofs,
Affiliation Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America
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Alejandro Sweet-Cordero,
Affiliation Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America
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Sanjiv S. Gambhir,
Affiliation Department of Radiology, Stanford University School of Medicine, Stanford, California, United States of America
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Charles M. Rudin,
Affiliation Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland, United States of America
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Dean W. Felsher
* E-mail: tranp@jhmi.edu (PTT); dfelsher@stanford.edu (DWF)
Affiliation Departments of Medicine and Pathology, Division of Oncology, Stanford University School of Medicine, Stanford, California, United States of America
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Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis
- Phuoc T. Tran,
- Emelyn H. Shroff,
- Timothy F. Burns,
- Saravanan Thiyagarajan,
- Sandhya T. Das,
- Tahera Zabuawala,
- Joy Chen,
- Yoon-Jae Cho,
- Richard Luong,
- Pablo Tamayo
- Published: May 24, 2012
- https://doi.org/10.1371/journal.pgen.1002650