Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics

Michael A. Nalls; Javier Simon-Sanchez; J. Raphael Gibbs; Coro Paisan-Ruiz; Jose Tomas Bras; Toshiko Tanaka; Mar Matarin; Sonja Scholz; Charles Weitz; Tamara B. Harris; Luigi Ferrucci; John Hardy; Andrew B. Singleton

doi:10.1371/journal.pgen.1000415

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Open Access

Peer-reviewed

Research Article

Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics

Michael A. Nalls,

Affiliations Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Maryland, United States of America
⨯
Javier Simon-Sanchez,

Affiliations Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Unidad de Genética Molecular, Departamento de Genómica y Proteómica, Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain
⨯
J. Raphael Gibbs,

Affiliations Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom
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Coro Paisan-Ruiz,

Affiliation Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom
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Jose Tomas Bras,

Affiliation Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
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Toshiko Tanaka,

Affiliation Longitudinal Studies Section, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
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Mar Matarin,

Affiliation Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
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Sonja Scholz,

Affiliations Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom
⨯
Charles Weitz,

Affiliation Department of Anthropology, Biological Anthropology Program, Temple University, Philadelphia, Pennsylvania, United States of America
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Tamara B. Harris,

Affiliation Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Maryland, United States of America
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Luigi Ferrucci,

Affiliation Longitudinal Studies Section, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
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John Hardy,

Affiliation Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom
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Andrew B. Singleton

* E-mail: singleta@mail.nih.gov

Affiliations Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
⨯

Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics

Michael A. Nalls,
Javier Simon-Sanchez,
J. Raphael Gibbs,
Coro Paisan-Ruiz,
Jose Tomas Bras,
Toshiko Tanaka,
Mar Matarin,
Sonja Scholz,
Charles Weitz,
Tamara B. Harris

Published: March 13, 2009
https://doi.org/10.1371/journal.pgen.1000415

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Homozygosity
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Single nucleotide polymorphisms
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Time measurement
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Inbreeding
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