Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

Peter F Zipfel; Matthew Edey; Stefan Heinen; Mihály Józsi; Heiko Richter; Joachim Misselwitz; Bernd Hoppe; Danny Routledge; Lisa Strain; Anne E Hughes; Judith A Goodship; Christoph Licht; Timothy H. J Goodship; Christine Skerka

doi:10.1371/journal.pgen.0030041

Loading metrics

Open Access

Peer-reviewed

Research Article

Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

Peter F Zipfel,

Affiliations Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany , Friedrich Schiller University, Jena, Germany
⨯
Matthew Edey,

Affiliation Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Stefan Heinen,

Affiliation Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
⨯
Mihály Józsi,

Affiliation Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
⨯
Heiko Richter,

Affiliation Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
⨯
Joachim Misselwitz,

Affiliation Friedrich Schiller University, Jena, Germany
⨯
Bernd Hoppe,

Affiliation Children's Hospital of the University of Cologne, Cologne, Germany
⨯
Danny Routledge,

Affiliation Northern Molecular Genetics Service Laboratory, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
⨯
Lisa Strain,

Affiliation Northern Molecular Genetics Service Laboratory, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
⨯
Anne E Hughes,

Affiliation Department of Medical Genetics, Queen's University, Belfast, United Kingdom
⨯
Judith A Goodship,

Affiliation Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Christoph Licht,

Affiliation Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada
⨯
Timothy H. J Goodship,

Affiliation Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Christine Skerka

*To whom correspondence should be addressed. E-mail: christine.skerka@hki-jena.de

Affiliation Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
⨯

Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

Peter F Zipfel,
Matthew Edey,
Stefan Heinen,
Mihály Józsi,
Heiko Richter,
Joachim Misselwitz,
Bernd Hoppe,
Danny Routledge,
Lisa Strain,
Anne E Hughes

Published: March 16, 2007
https://doi.org/10.1371/journal.pgen.0030041

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Red blood cells
Is the Subject Area "Red blood cells" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
Hemolytic-uremic syndrome
Is the Subject Area "Hemolytic-uremic syndrome" applicable to this article?

Thanks for your feedback.
Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.
Complement activation
Is the Subject Area "Complement activation" applicable to this article?

Thanks for your feedback.
Homologous recombination
Is the Subject Area "Homologous recombination" applicable to this article?

Thanks for your feedback.
Polymerase chain reaction
Is the Subject Area "Polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.