Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions

• Lai H. Wong,

  Affiliation Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada

  http://orcid.org/0000-0001-8653-2734

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• Sunita Sinha,

  Affiliation Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada

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• Julien R. Bergeron,

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Joseph C. Mellor,

  Affiliation seqWell, Inc., Beverly, Massachusetts, United States of America

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• Guri Giaever,

  Affiliation Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada

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• Patrick Flaherty ,

  * E-mail: flaherty@math.umass.edu (PF); corey.nislow@ubc.ca (CN)

  Affiliation Department of Mathematics and Statistics, University of Massachusetts, Amherst, Massachusetts, United States of America

  http://orcid.org/0000-0001-6097-6572

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• Corey Nislow

  * E-mail: flaherty@math.umass.edu (PF); corey.nislow@ubc.ca (CN)

  Affiliation Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada

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