The Challenges of Mitochondrial Replacement

Patrick F. Chinnery; Lyndsey Craven; Shoukhrat Mitalipov; James B. Stewart; Mary Herbert; Douglass M. Turnbull

doi:10.1371/journal.pgen.1004315

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The Challenges of Mitochondrial Replacement

Patrick F. Chinnery,

Affiliations Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, United Kingdom
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Lyndsey Craven,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
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Shoukhrat Mitalipov,

Affiliation Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America
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James B. Stewart,

Affiliation Max Planck Institute for Biology of Ageing, Cologne, Germany
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Mary Herbert,

Affiliations Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, Newcastle Fertility Centre, International Centre for Life, Newcastle University, Newcastle upon Tyne, United Kingdom
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Douglass M. Turnbull

* E-mail: doug.turnbull@newcastle.ac.uk

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯

The Challenges of Mitochondrial Replacement

Patrick F. Chinnery,
Lyndsey Craven,
Shoukhrat Mitalipov,
James B. Stewart,
Mary Herbert,
Douglass M. Turnbull

Published: April 24, 2014
https://doi.org/10.1371/journal.pgen.1004315

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Misrepresentation

Posted by sanewman on 02 Jun 2014 at 23:51 GMT

Why are these procedures (Maternal Spindle Transfer, Pronuclear Transfer) continually referred to as "mitochondrial replacement"? At what point is anyone's mitochondria being replaced? Nuclear DNA is placed in an enucleated egg. Mitochondria are in no way being manipulated except by the social convention that the nuclear DNA donor will own the resulting egg by a legal contract.

No competing interests declared.

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The Challenges of Mitochondrial Replacement

The Challenges of Mitochondrial Replacement

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Misrepresentation

Posted by sanewman on 02 Jun 2014 at 23:51 GMT