TY - JOUR T1 - Loss of Gnas Imprinting Differentially Affects REM/NREM Sleep and Cognition in Mice A1 - Lassi, Glenda A1 - Ball, Simon T. A1 - Maggi, Silvia A1 - Colonna, Giovanni A1 - Nieus, Thierry A1 - Cero, Cheryl A1 - Bartolomucci, Alessandro A1 - Peters, Jo A1 - Tucci, Valter Y1 - 2012/05/10 N2 - Author Summary REM and NREM sleep are two distinct stages of the sleeping brain that are involved in the modulation of metabolic, physiological, and cognitive processes. Clinical evidence suggests that epigenetic mechanisms, such as genomic imprinting, play a role in sleep. Here we show that REM and NREM brain states are differentially modulated by the maternally imprinted gene Gnas. In particular, a mutation resulting in loss of imprinted expression of Gnas enhances NREM–dependent physiologic and cognitive functions while repressing REM and REM-linked functions. This is the first experimental demonstration of a specific effect of genomic imprinting on sleep states and their associated effects on cognition. JF - PLOS Genetics JA - PLOS Genetics VL - 8 IS - 5 UR - https://doi.org/10.1371/journal.pgen.1002706 SP - e1002706 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pgen.1002706 ER -