About the Authors

Shiyu Xu

Contributed equally to this work with: Shiyu Xu, Gang Li

Roles Data curation, Methodology

Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Gang Li

Contributed equally to this work with: Shiyu Xu, Gang Li

Roles Data curation, Methodology

Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Xin Ye

Roles Data curation, Methodology

Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Dongsheng Chen

Roles Data curation, Methodology

Current Address: The College of Life Sciences, Anhui Normal University, Wuhu, Anhui, People’s Republic of China

Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Zhihua Chen

Roles Data curation, Methodology

Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Zhen Xu

Roles Data curation, Methodology

Current Address: Department of Neurosurgery, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Moretti Daniele

Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Translational and Discovery Research, IRBM SpA, Pomezia (RM), Italy

Sara Tambone

Roles Data curation

Affiliation Department of Translational and Discovery Research, IRBM SpA, Pomezia (RM), Italy

Alessandra Ceccacci

Roles Data curation

Affiliation Department of Translational and Discovery Research, IRBM SpA, Pomezia (RM), Italy

Licia Tomei

Roles Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Translational and Discovery Research, IRBM SpA, Pomezia (RM), Italy

Lili Ye

Roles Data curation

Affiliation The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Yue Yu

Roles Data curation

Affiliations The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America, Programs in Genetics and Epigenetics and Neuroscience, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, United States of America

Amanda Solbach

Roles Data curation

Affiliations The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America, Programs in Genetics and Epigenetics and Neuroscience, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, United States of America

Stephen M. Farmer

Roles Data curation

Affiliations The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America, Program in Biochemistry and Cell Biology, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, United States of America

Erin Furr Stimming

Roles Formal analysis

Affiliation Department of Neurology, HDSA Center of Excellence, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

George McAllister

Roles Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation CHDI Management/CHDI Foundation, 350 Seventh Ave, New York, New York, United States of America

Deanna M. Marchionini

Roles Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation CHDI Management/CHDI Foundation, 350 Seventh Ave, New York, New York, United States of America

Sheng Zhang

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

Sheng.Zhang@uth.tmc.edu

Affiliations The Brown Foundation Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America, Programs in Genetics and Epigenetics and Neuroscience, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (MD Anderson UTHealth GSBS), Houston, Texas, United States of America, Department of Neurobiology and Anatomy, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: GM and DM are employed by CHDI Management, Inc. as advisors to CHDI Foundation, Inc., and declare no conflict of interest. CHDI Foundation is a nonprofit biomedical research organization exclusively dedicated to collaboratively developing therapeutics that substantially improve the lives of those affected by Huntington’s disease. CHDI Foundation conducts research in a number of different ways; for the purposes of this manuscript, all research was conceptualized, planned, and directed by all authors and conducted at the University of Texas Health Science Center at Houston (UTHealth) or the CHDI-supported contract research organization IRBM. This does not alter our adherence to PLOS Genetics policies on sharing data and materials.