About the Authors

Amanda J. Craig

Roles Conceptualization, Formal analysis, Investigation, Resources, Visualization, Writing – original draft, Writing – review & editing

‡ These authors share first authorship on this work.

Affiliation Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Teresa Garcia-Lezana

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

‡ These authors share first authorship on this work.

Affiliation Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Marina Ruiz de Galarreta

Roles Investigation, Methodology, Resources

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Department of Oncological Sciences, The Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Precision Immunology Institute at Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Carlos Villacorta-Martin

Roles Data curation

Affiliation Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Edgar G. Kozlova

Roles Data curation, Formal analysis

Affiliations Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Sebastiao N. Martins-Filho

Roles Investigation, Resources

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Canada

Johann von Felden

Roles Investigation, Resources

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Mehmet Eren Ahsen

Roles Data curation, Formal analysis

Affiliation Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Erin Bresnahan

Roles Investigation, Methodology, Resources

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Department of Oncological Sciences, The Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Precision Immunology Institute at Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Gabriela Hernandez-Meza

Roles Investigation

Affiliation Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Ismail Labgaa

Roles Investigation, Resources

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Department of Visceral Surgery, Lausanne University Hospital CHUV, Lausanne, Switzerland

Delia D’Avola

Roles Resources

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Liver Unit and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Clínica Universidad de Navarra, Pamplona, Spain

Myron Schwartz

Roles Resources

Affiliation Department of Surgery, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Josep M. Llovet

Roles Supervision, Writing – review & editing

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Translational Research Laboratory, BCLC Group, IDIBAPS, Hospital Clinic, Universitat de Barcelona, Catalonia and Madrid, Spain, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain

Daniela Sia

Roles Writing – review & editing

Affiliation Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Swan Thung

Roles Investigation, Resources

Affiliation Department of Pathology, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Bojan Losic

Roles Conceptualization, Data curation, Methodology

Affiliations Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Amaia Lujambio

Roles Investigation, Methodology, Resources

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Department of Oncological Sciences, The Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Precision Immunology Institute at Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Augusto Villanueva

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

augusto.villanueva@mssm.edu

Affiliations Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America, Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: AL has received grant support from Pfizer and Genentech, and lecture fees from Exelixis for unrelated projects. MRdG has received grant support from Genentech for unrelated projects. AV has received consulting fees from Guidepoint and Fujifilm; advisory board fees from Exact Sciences, Nucleix and NGM Pharmaceuticals. JML has received grant support from Bayer HealthCare Pharmaceuticals, Eisai Inc, Bristol-Myers Squibb, Boehringer-Ingelheim and Ipsen and consulting fees from Bayer HealthCare Pharmaceuticals, Merck, Eisai Inc, Bristol-Myers Squibb, Celsion Corporation, Eli Lilly, Roche, Genentech, Glycotest, Nucleix, Can-Fite Biopharma, AstraZeneca, and Exelixis.