About the Authors

Carles Vilariño-Güell

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

carles@can.ubc.ca

Affiliation Department of Medical Genetics, University of British Columbia, Vancouver, Canada

Alexander Zimprich

Roles Formal analysis, Funding acquisition, Resources, Writing – review & editing

Affiliation Department of Neurology, Medical University of Vienna, Vienna, Austria

Filippo Martinelli-Boneschi

Roles Data curation, Funding acquisition, Investigation, Supervision, Writing – review & editing

Affiliations Laboratory of Human Genetics of Neurological Disorders, CNS Inflammatory Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy, MS Unit and Department of Neurology, IRCCS Policlinico San Donato, Milan, Italy, Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

Bruno Herculano

Roles Data curation, Investigation, Writing – review & editing

Affiliation Townsend Family Laboratories, Department of Psychiatry, University of British Columbia, Vancouver, Canada

Zhe Wang

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations Townsend Family Laboratories, Department of Psychiatry, University of British Columbia, Vancouver, Canada, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of the Capital Medical University, Beijing, China

Fuencisla Matesanz

Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, Granada, Spain

Elena Urcelay

Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

Affiliations Immunology Dept, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain, Red Española de Esclerosis Múltiple REEM, Madrid, Spain

Koen Vandenbroeck

Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing

Affiliations Achucarro Basque Center for Neuroscience, Universidad del País Vasco (UPV/EHU), Leioa, Spain, Ikerbasque, Basque Foundation for Science, Bilbao, Spain

Laura Leyva

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Red Española de Esclerosis Múltiple REEM, Madrid, Spain, Instituto de Investigación Biomédica de Málaga-IBIMA, Unidad de Gestion Clínica de Neurociencias, Hospital Regional Universitario de Málaga, Málaga, Spain

Denis Gris

Roles Investigation, Writing – review & editing

Affiliation Division of Immunology, Department of Pediatrics, CR-CHUS, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Canada

Charbel Massaad

Roles Investigation, Writing – review & editing

Affiliation Toxicology, Pharmacology and Cell Signalisation—UMR-S 1124 Université Paris Descartes, Paris, France

Jacqueline A. Quandt

Roles Investigation, Writing – review & editing

Affiliation Department of Pathology, Faculty of Medicine, University of British Columbia, Vancouver, Canada

Anthony L. Traboulsee

Roles Funding acquisition, Investigation, Writing – review & editing

Affiliation Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada

Mary Encarnacion

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Medical Genetics, University of British Columbia, Vancouver, Canada

Cecily Q. Bernales

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Medical Genetics, University of British Columbia, Vancouver, Canada

Jordan Follett

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Medical Genetics, University of British Columbia, Vancouver, Canada

Irene M. Yee

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Medical Genetics, University of British Columbia, Vancouver, Canada

Maria G. Criscuoli

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Medical Genetics, University of British Columbia, Vancouver, Canada

Angela Deutschländer

Roles Investigation, Supervision, Writing – review & editing

Affiliations Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, United States of America, Department of Clinical Genomics, Mayo Clinic Florida, Jacksonville, FL, United States of America, Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, United States of America

Eva M. Reinthaler

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Neurology, Medical University of Vienna, Vienna, Austria

Tobias Zrzavy

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Neurology, Medical University of Vienna, Vienna, Austria

Elisabetta Mascia

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Laboratory of Human Genetics of Neurological Disorders, CNS Inflammatory Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy

Andrea Zauli

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Laboratory of Human Genetics of Neurological Disorders, CNS Inflammatory Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy

Federica Esposito

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Laboratory of Human Genetics of Neurological Disorders, CNS Inflammatory Unit, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy

Antonio Alcina

Roles Data curation, Funding acquisition, Investigation, Resources, Writing – review & editing

Affiliation Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, Granada, Spain

Guillermo Izquierdo

Roles Data curation, Investigation, Writing – review & editing

Affiliation Unidad de Esclerosis Múltiple, Hospital Virgen Macarena, Sevilla, Spain

Laura Espino-Paisán

Roles Data curation, Investigation, Writing – review & editing

Affiliations Immunology Dept, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain, Red Española de Esclerosis Múltiple REEM, Madrid, Spain

Jorge Mena

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Achucarro Basque Center for Neuroscience, Universidad del País Vasco (UPV/EHU), Leioa, Spain

Alfredo Antigüedad

Roles Resources, Supervision, Writing – review & editing

Affiliation Neurology Department, Hospital Universitario de Cruces, S/N, Baracaldo, Spain

Patricia Urbaneja-Romero

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Red Española de Esclerosis Múltiple REEM, Madrid, Spain, Instituto de Investigación Biomédica de Málaga-IBIMA, Unidad de Gestion Clínica de Neurociencias, Hospital Regional Universitario de Málaga, Málaga, Spain

Jesús Ortega-Pinazo

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Instituto de Investigación Biomédica de Málaga-IBIMA, Unidad de Gestion Clínica de Neurociencias, Hospital Regional Universitario de Málaga, Málaga, Spain

Weihong Song

Contributed equally to this work with: Weihong Song, A. Dessa Sadovnick

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Townsend Family Laboratories, Department of Psychiatry, University of British Columbia, Vancouver, Canada

A. Dessa Sadovnick

Contributed equally to this work with: Weihong Song, A. Dessa Sadovnick

Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

Affiliations Department of Medical Genetics, University of British Columbia, Vancouver, Canada, Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada

Competing Interests

The authors have declared that no competing interests exist.