About the Authors

Ying Chen

Contributed equally to this work with: Ying Chen, Melissa A. Gilbert

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Human Genetics, Department of Pediatrics, at The Children's Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Melissa A. Gilbert

Contributed equally to this work with: Ying Chen, Melissa A. Gilbert

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Christopher M. Grochowski

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Deborah McEldrew

Roles Data curation, Writing – review & editing

Affiliation Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Jessica Llewellyn

Roles Data curation

Affiliation Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Orith Waisbourd-Zinman

Roles Investigation

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics at The Children's Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

Hakon Hakonarson

Roles Resources, Writing – review & editing

Affiliations Division of Human Genetics, Department of Pediatrics, at The Children's Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Joan E. Bailey-Wilson

Roles Resources, Writing – review & editing

Affiliation Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America

Pierre Russo

Roles Resources, Writing – review & editing

Affiliation Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Rebecca G. Wells

Roles Resources, Writing – review & editing

Affiliation Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Kathleen M. Loomes

Roles Conceptualization, Data curation, Funding acquisition, Writing – review & editing

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics at The Children's Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Nancy B. Spinner

Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – review & editing

spinner@email.chop.edu (NBS); devoto@email.chop.edu (MD)

Affiliation Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Marcella Devoto

Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – review & editing

spinner@email.chop.edu (NBS); devoto@email.chop.edu (MD)

Affiliations Division of Human Genetics, Department of Pediatrics, at The Children's Hospital of Philadelphia, and The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Molecular Medicine, Sapienza University, Rome, Italy

Competing Interests

The authors have declared that no competing interests exist.