About the Authors

Ayako Fukunaka

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan, Laboratory of Developmental Biology & Metabolism, Institute for Molecular & Cellular Regulation, Gunma University, Maebashi, Gunma, Japan, AMED-JST-CREST Program, Tokyo, Japan

Toshiyuki Fukada

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan, Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo, Japan, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

Jinhyuk Bhin

Roles Methodology, Writing – original draft

Affiliation Department of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Luka Suzuki

Roles Validation

Affiliation Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan

Takamasa Tsuzuki

Roles Methodology

Affiliation Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan

Yuri Takamine

Roles Methodology

Affiliation Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan

Bum-Ho Bin

Roles Methodology, Validation

Affiliation Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo, Japan

Toshinori Yoshihara

Roles Methodology

Affiliation Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan

Noriko Ichinoseki-Sekine

Roles Methodology

Affiliation Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan

Hisashi Naito

Roles Methodology

Affiliation Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan

Takeshi Miyatsuka

Roles Validation

Affiliation Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan

Shinzaburo Takamiya

Roles Methodology, Validation

Affiliation Department of Tropical Medicine and Parasitology, Graduate School of Medicine, Juntendo University, Tokyo, Japan

Tsutomu Sasaki

Roles Methodology, Validation

Affiliation Laboratory of Metabolic Signaling, Institute for Molecular & Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

Takeshi Inagaki

Roles Methodology, Validation

Affiliation Laboratory of Epigenetics and Metabolism, Institute for Molecular & Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

Tadahiro Kitamura

Roles Methodology

Affiliation Laboratory of Metabolic Signaling, Institute for Molecular & Cellular Regulation, Gunma University, Maebashi, Gunma, Japan

Shingo Kajimura

Roles Methodology, Resources, Validation, Writing – review & editing

Affiliations UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California–San Francisco, San Francisco, United States of America, PRESTO-JST, Tokyo, Japan

Hirotaka Watada

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliations Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan, Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan, Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan, Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan

Yoshio Fujitani

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

fujitani@gunma-u.ac.jp

Affiliations Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan, Laboratory of Developmental Biology & Metabolism, Institute for Molecular & Cellular Regulation, Gunma University, Maebashi, Gunma, Japan, AMED-JST-CREST Program, Tokyo, Japan, Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: HW has received lecture fees from Daiichi Sankyo Co. Ltd., (Daiichi Sankyo), Takeda Pharmaceutical Co. Ltd. (Takeda), MSD, Sanofi, Ono Pharmaceutical Co. Ltd. (Ono), Novartis Pharma K.K. (Novartis), Astellas Pharma, Inc. (Astellas), Sumitomo Dainippon Pharma Co. Ltd. (Sumitomo Dainippon), Mitsubishi Tanabe Pharma Corporation (Mitsubishi Tanabe), Novo Nordisk Pharma Ltd. (Novo Nordisk), and Sanwa Kagaku Kenkyusho Co. Ltd. (Sanwa Kagaku), and research funding from Sanofi, Novo Nordisk, Novartis, AstraZeneca, Sanwa Kagaku, Ono, MSD, Boehringer Ingelheim, Kissei Pharmaceutical Co. Ltd., Takeda, Daiichi Sankyo, and Eli Lilly & Co. (Eli Lilly).