Probing Xist RNA Structure in Cells Using Targeted Structure-Seq

Rui Fang; Walter N. Moss; Michael Rutenberg-Schoenberg; Matthew D. Simon

doi:10.1371/journal.pgen.1005668

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Open Access

Peer-reviewed

Research Article

Probing Xist RNA Structure in Cells Using Targeted Structure-Seq

Rui Fang ,

Contributed equally to this work with: Rui Fang, Walter N. Moss

Affiliations Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America, Chemical Biology Institute, Yale University, West Haven, Connecticut, United States of America
⨯
Walter N. Moss ,

Contributed equally to this work with: Rui Fang, Walter N. Moss

Affiliation Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America
⨯
Michael Rutenberg-Schoenberg,

Affiliations Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America, Chemical Biology Institute, Yale University, West Haven, Connecticut, United States of America
⨯
Matthew D. Simon

* E-mail: matthew.simon@yale.edu

Affiliations Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America, Chemical Biology Institute, Yale University, West Haven, Connecticut, United States of America
⨯

Probing Xist RNA Structure in Cells Using Targeted Structure-Seq

Rui Fang,
Walter N. Moss,
Michael Rutenberg-Schoenberg,
Matthew D. Simon

Published: December 8, 2015
https://doi.org/10.1371/journal.pgen.1005668

About the Authors

Rui Fang

Contributed equally to this work with: Rui Fang, Walter N. Moss

Affiliations Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America, Chemical Biology Institute, Yale University, West Haven, Connecticut, United States of America

Walter N. Moss

Contributed equally to this work with: Rui Fang, Walter N. Moss

Affiliation Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America

Michael Rutenberg-Schoenberg

Matthew D. Simon

* E-mail: matthew.simon@yale.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RF MDS. Performed the experiments: RF. Wrote the paper: RF WNM MDS. Probing data analysis: RF MRS. RNA structure modeling: WNM.

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RNA structure
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RNA sequencing
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Long non-coding RNA
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Nucleotides
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Ribosomal RNA
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Sequence alignment
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Point mutation
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RNA analysis
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