About the Authors

Tianxiao Huan

Contributed equally to this work with: Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Tõnu Esko

Contributed equally to this work with: Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann

Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Division of Endocrinology, Children’s Hospital Boston, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Marjolein J. Peters

Contributed equally to this work with: Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann

Affiliations Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands, Netherlands Genomics Initiative–sponsored Netherlands Consortium for Healthy Aging (NGI‐NCHA), Leiden and Rotterdam, The Netherlands

Luke C. Pilling

Contributed equally to this work with: Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann

Affiliation Epidemiology and Public Health Group, Medical School, University of Exeter, Exeter, United Kingdom

Katharina Schramm

Contributed equally to this work with: Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann

Affiliations Institute of Human Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany, Institute of Human Genetics, Technische Universität München, München, Germany

Claudia Schurmann

Contributed equally to this work with: Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann

Affiliations Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany, The Charles Bronfman Institute for Personalized Medicine, Genetics of Obesity & Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Brian H. Chen

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Chunyu Liu

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Roby Joehanes

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America, Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Hebrew SeniorLife, Boston, Boston, Massachusetts, United States of America

Andrew D. Johnson

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Cardiovascular Epidemiology and Human Genomics Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, Maryland, United States of America

Chen Yao

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Sai-xia Ying

Affiliation Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland, United States of America

Paul Courchesne

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Lili Milani

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Nalini Raghavachari

Affiliation Division of Geriatrics and Clinical Gerontology National Institute on Aging, Bethesda, Maryland, United States of America

Richard Wang

Affiliation Genomics Core facility Genetics & Developmental Biology Center, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Poching Liu

Affiliation Genomics Core facility Genetics & Developmental Biology Center, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Eva Reinmaa

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Abbas Dehghan

Affiliations Netherlands Genomics Initiative–sponsored Netherlands Consortium for Healthy Aging (NGI‐NCHA), Leiden and Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

Albert Hofman

Affiliations Netherlands Genomics Initiative–sponsored Netherlands Consortium for Healthy Aging (NGI‐NCHA), Leiden and Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

André G. Uitterlinden

Affiliations Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands, Netherlands Genomics Initiative–sponsored Netherlands Consortium for Healthy Aging (NGI‐NCHA), Leiden and Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands

Dena G. Hernandez

Affiliation Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America

Stefania Bandinelli

Affiliation Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy

Andrew Singleton

Affiliation Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America

David Melzer

Affiliation Epidemiology and Public Health Group, Medical School, University of Exeter, Exeter, United Kingdom

Andres Metspalu

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Maren Carstensen

Affiliations Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Düsseldorf, Germany

Harald Grallert

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, German Center for Diabetes Research (DZD e.V.), Partner Munich, Munich, Germany

Christian Herder

Affiliations Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Düsseldorf, Germany

Thomas Meitinger

Affiliations Institute of Human Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany, Institute of Human Genetics, Technische Universität München, München, Germany, DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

Annette Peters

Affiliations Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, German Center for Diabetes Research (DZD e.V.), Partner Munich, Munich, Germany, DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

Michael Roden

Affiliations Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, German Center for Diabetes Research (DZD e.V.), Partner Düsseldorf, Düsseldorf, Germany, Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany

Melanie Waldenberger

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

Marcus Dörr

Affiliations University Medicine Greifswald, Department of Internal Medicine B—Cardiology, Greifswald, Germany, DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany

Stephan B. Felix

Affiliations University Medicine Greifswald, Department of Internal Medicine B—Cardiology, Greifswald, Germany, DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany

Tanja Zeller

Affiliations Universitäres Herzzentrum Hamburg, Hamburg, Germany, DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany

International Consortium for Blood Pressure GWAS (ICBP)

Membership of the International Consortium for Blood Pressure GWAS (ICBP) is listed in the section “Members of International Consortium for Blood Pressure GWAS (ICBP).”

Ramachandran Vasan

Affiliation The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

Christopher J. O'Donnell

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Peter J. Munson

Affiliation Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland, United States of America

Xia Yang

Levyd@nih.gov (DL); ferruccilu@mail.nih.gov (LF); j.vanmeurs@erasmusmc.nl (JBJvM); prokisch@helmholtz-muenchen.de (HP); voelker@uni-greifswald.de (UV); xyang123@ucla.edu (XY)

Affiliation Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, United States of America

Holger Prokisch

Levyd@nih.gov (DL); ferruccilu@mail.nih.gov (LF); j.vanmeurs@erasmusmc.nl (JBJvM); prokisch@helmholtz-muenchen.de (HP); voelker@uni-greifswald.de (UV); xyang123@ucla.edu (XY)

Affiliations Institute of Human Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany, Institute of Human Genetics, Technische Universität München, München, Germany

Uwe Völker

Levyd@nih.gov (DL); ferruccilu@mail.nih.gov (LF); j.vanmeurs@erasmusmc.nl (JBJvM); prokisch@helmholtz-muenchen.de (HP); voelker@uni-greifswald.de (UV); xyang123@ucla.edu (XY)

Affiliations Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany, DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany

Joyce B. J. van Meurs

Levyd@nih.gov (DL); ferruccilu@mail.nih.gov (LF); j.vanmeurs@erasmusmc.nl (JBJvM); prokisch@helmholtz-muenchen.de (HP); voelker@uni-greifswald.de (UV); xyang123@ucla.edu (XY)

Affiliations Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands, Netherlands Genomics Initiative–sponsored Netherlands Consortium for Healthy Aging (NGI‐NCHA), Leiden and Rotterdam, The Netherlands

Luigi Ferrucci

Levyd@nih.gov (DL); ferruccilu@mail.nih.gov (LF); j.vanmeurs@erasmusmc.nl (JBJvM); prokisch@helmholtz-muenchen.de (HP); voelker@uni-greifswald.de (UV); xyang123@ucla.edu (XY)

Affiliation Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Daniel Levy

Levyd@nih.gov (DL); ferruccilu@mail.nih.gov (LF); j.vanmeurs@erasmusmc.nl (JBJvM); prokisch@helmholtz-muenchen.de (HP); voelker@uni-greifswald.de (UV); xyang123@ucla.edu (XY)

Affiliations The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: NR RW PL PC MC. Analyzed the data: TH TE MJP LCP KS CS BHC CL RJ. Wrote the paper: TH TE MJP LCP KS CS DL LF JBJvM HP UV XY. Designed, directed, and supervised the project: DL LF JBJvM HP UV XY CH. Participated in revising and editing the manuscripts: ADJ CY SxY LM NR ER AD AH AGU DGH SB AS DM AM MC HG CH TM AP MR MW MD SBF TZ RV CJO PJM.