About the Authors

Lily Paemka

Contributed equally to this work with: Lily Paemka, Vinit B. Mahajan, Salleh N. Ehaideb

Affiliations Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Program in Genetics, The University of Iowa, Iowa City, Iowa, United States of America

Vinit B. Mahajan

Contributed equally to this work with: Lily Paemka, Vinit B. Mahajan, Salleh N. Ehaideb

Affiliations Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, United States of America, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Department of Biology, The University of Iowa, Iowa City, Iowa, United States of America

Salleh N. Ehaideb

Contributed equally to this work with: Lily Paemka, Vinit B. Mahajan, Salleh N. Ehaideb

Affiliations Department of Biology, The University of Iowa, Iowa City, Iowa, United States of America, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, KSA

Jessica M. Skeie

Affiliations Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, United States of America, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

Men Chee Tan

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Australia

Shu Wu

Affiliation Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America

Allison J. Cox

Affiliations Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America, Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, Iowa, United States of America

Levi P. Sowers

Affiliation Interdisciplinary Graduate Program of Neuroscience, Department of Veterans Affairs Medical Center, Iowa City, Iowa, United States of America

Jozef Gecz

Affiliation School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia

Lachlan Jolly

Affiliation School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia

Polly J. Ferguson

Affiliations Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

Benjamin Darbro

Affiliations Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Program in Genetics, The University of Iowa, Iowa City, Iowa, United States of America, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America

Amy Schneider

Affiliation Epilepsy Research Centre, Department of Medicine, University of Melbourne, The Florey, Austin Health, Heidelberg, Melbourne, Australia

Ingrid E. Scheffer

Affiliation Epilepsy Research Centre, Department of Medicine, University of Melbourne, The Florey, Austin Health, Heidelberg, Melbourne, Australia

Gemma L. Carvill

Affiliation Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

Heather C. Mefford

Affiliation Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

Hatem El-Shanti

Affiliations Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America, Qatar Biomedical Research Institute Medical Genetics Center, Doha, Qatar

Stephen A. Wood

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Australia

J. Robert Manak

alexander-bassuk@uiowa.edu (AGB); john-manak@uiowa.edu (JRM)

Affiliations Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Program in Genetics, The University of Iowa, Iowa City, Iowa, United States of America, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Department of Biology, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Graduate Program in Molecular and Cellular Biology, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Graduate Program in Neuroscience, The University of Iowa, Iowa City, Iowa, United States of America

Alexander G. Bassuk

alexander-bassuk@uiowa.edu (AGB); john-manak@uiowa.edu (JRM)

Affiliations Department of Pediatrics, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Program in Genetics, The University of Iowa, Iowa City, Iowa, United States of America, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Graduate Program in Molecular and Cellular Biology, The University of Iowa, Iowa City, Iowa, United States of America, Interdisciplinary Graduate Program in Neuroscience, The University of Iowa, Iowa City, Iowa, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LP VBM SNE JRM HCM PJF MCT SW LJ HES AGB. Performed the experiments: LP SNE JRM GCL AS MCT SW LJ. Analyzed the data: AGB LP JMS AJC GLC BD IES LPS. Contributed reagents/materials/analysis tools: AGB JRM HES VM JG SW HCM. Wrote the paper: LP VM AGB JRM.