A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics

James Liley; Chris Wallace

doi:10.1371/journal.pgen.1004926

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Open Access

Peer-reviewed

Research Article

A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics

James Liley,

Affiliation JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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Chris Wallace

* E-mail: chris.wallace@cimr.cam.uk

Affiliations JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom
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A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics

James Liley,
Chris Wallace

Published: February 6, 2015
https://doi.org/10.1371/journal.pgen.1004926
See the preprint

About the Authors

James Liley

Affiliation JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

Chris Wallace

* E-mail: chris.wallace@cimr.cam.uk

Affiliations JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: The JDRF/Wellcome Trust Diabetes and Inflammation Laboratory receives funding from Hoffmann La Roche and Eli-Lilly and Company. ImmunoBase is funded in part by Eli-Lilly and Company.

Author Contributions

Conceived and designed the experiments: JL CW. Performed the experiments: JL. Analyzed the data: JL. Contributed reagents/materials/analysis tools: JL CW. Wrote the paper: JL CW.

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Single nucleotide polymorphisms
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Genome-wide association studies
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Genomics
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Genetics of disease
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Autoimmune diseases
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Diabetes mellitus
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Etiology
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Genome analysis
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