About the Authors
- Inga Prokopenko
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Contributed equally to this work with: Inga Prokopenko, Wenny Poon, Reedik Mägi
Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom
- Wenny Poon
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Contributed equally to this work with: Inga Prokopenko, Wenny Poon, Reedik Mägi
Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Reedik Mägi
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Contributed equally to this work with: Inga Prokopenko, Wenny Poon, Reedik Mägi
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Estonian Genome Center, University of Tartu, Tartu, Estonia
- Rashmi Prasad B
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- S. Albert Salehi
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Peter Almgren
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Peter Osmark
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Nabila Bouatia-Naji
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Affiliations University of Lille Nord de France, Lille, France, CNRS UMR8199, Institut Pasteur de Lille, Lille, France, INSERM U970, Paris Cardiovascular Research Center PARCC, Paris, France
- Nils Wierup
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Affiliation Department of Clinical Science, Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö, Sweden
- Tove Fall
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Affiliation Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
- Alena Stančáková
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Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
- Adam Barker
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Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
- Vasiliki Lagou
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Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Clive Osmond
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Affiliation MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom
- Weijia Xie
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Affiliation Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
- Jari Lahti
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Affiliations Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland, Folkhälsan Research Centre, Helsinki, Finland
- Anne U. Jackson
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Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
- Yu-Ching Cheng
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Affiliation Division of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Jie Liu
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Affiliation Division of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Jeffrey R. O'Connell
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Affiliation Division of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
- Paul A. Blomstedt
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Affiliations Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Department of Mathematics, Åbo Akademi University, Turku, Finland
- Joao Fadista
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Sami Alkayyali
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Tasnim Dayeh
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Affiliation Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University, CRC, Scania University Hospital, Malmö, Sweden
- Emma Ahlqvist
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Jalal Taneera
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Cecile Lecoeur
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Affiliations University of Lille Nord de France, Lille, France, CNRS UMR8199, Institut Pasteur de Lille, Lille, France
- Ashish Kumar
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Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland
- Ola Hansson
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Karin Hansson
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Affiliation Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden
- Benjamin F. Voight
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Affiliation Department of Pharmacology and Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
- Hyun Min Kang
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Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
- Claire Levy-Marchal
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Affiliations INSERM - Institut de Santé Publique, Paris, France, INSERM CIC EC 05, Hôpital Robert Debré, Paris, France
- Vincent Vatin
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Affiliations University of Lille Nord de France, Lille, France, CNRS UMR8199, Institut Pasteur de Lille, Lille, France
- Aarno Palotie
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Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, Program in Medical and Population Genetics and Genetics Analysis Platform, The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusettes, United States of America
- Ann-Christine Syvänen
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Affiliation Molecular Medicine, Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
- Andrea Mari
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Affiliation CNR Institute of Biomedical Engineering, Padova, Italy
- Michael N. Weedon
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Affiliation Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
- Ruth J. F. Loos
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Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
- Ken K. Ong
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Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
- Peter Nilsson
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Affiliation Department of Clinical Science, Internal Medicine, Skåne University Hospital Malmö, Malmö, Sweden
- Bo Isomaa
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Affiliations Folkhälsan Research Centre, Helsinki, Finland, Department of Social Service and Health Care, Jakobstad, Finland
- Tiinamaija Tuomi
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Affiliations Folkhälsan Research Centre, Helsinki, Finland, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
- Nicholas J. Wareham
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Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
- Michael Stumvoll
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Affiliations University of Leipzig, Department of Medicine, Leipzig, Germany, University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany
- Elisabeth Widen
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Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
- Timo A. Lakka
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Affiliations Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
- Claudia Langenberg
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Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
- Anke Tönjes
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Affiliations University of Leipzig, Department of Medicine, Leipzig, Germany, University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany
- Rainer Rauramaa
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Affiliations Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
- Johanna Kuusisto
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Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
- Timothy M. Frayling
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Affiliation Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom
- Philippe Froguel
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Affiliations Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, United Kingdom, University of Lille Nord de France, Lille, France, CNRS UMR8199, Institut Pasteur de Lille, Lille, France
- Mark Walker
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Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
- Johan G. Eriksson
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Affiliations Folkhälsan Research Centre, Helsinki, Finland, Helsinki University, Department of General Practice and Primary Health Care, Helsinki, Finland, Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland
- Charlotte Ling
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Affiliation Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University, CRC, Scania University Hospital, Malmö, Sweden
- Peter Kovacs
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Affiliations University of Leipzig, Department of Medicine, Leipzig, Germany, University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany
- Erik Ingelsson
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Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden
- Mark I. McCarthy
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Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kindom
- Alan R. Shuldiner
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Affiliations Division of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Baltimore Geriatric Research, Education and Clinical Center, Baltimore, Maryland, United States of America
- Kristi D. Silver
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Affiliations Division of Endocrinology Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Baltimore Geriatric Research, Education and Clinical Center, Baltimore, Maryland, United States of America
- Markku Laakso
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Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
- Leif Groop
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* E-mail: Leif.Groop@med.lu.se (LG); vlly@steno.dk, Valeriya.Lyssenko@med.lu.se (VL)
Affiliations Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
- Valeriya Lyssenko
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* E-mail: Leif.Groop@med.lu.se (LG); vlly@steno.dk, Valeriya.Lyssenko@med.lu.se (VL)
Affiliations Department of Clinical Science, Diabetes & Endocrinology, Lund University Diabetes Centre, Malmö, Sweden, Steno Diabetes Center A/S, Gentofte, Denmark
Competing Interests
I have read the journal's policy and we have the following conflicts: VLy declares that Steno Diabetes Center is owned by Novonordisk, PK is funded by Boehringer Ingelheim Foundation, TF received payment for lectures from MSD (Merck), AM is a consultant for Eli Lilly and Poxel and has received grants from Eli Lilly and Boehringer Ingelheim, BI has received payment for lectures from Boehringer Ingelheim, MSD, Novo Nordisk Farma and AstraZeneca, LG has been a consultant for and served on advisory boards for Sanofi-Aventis, GSK, Novartis, Merck, Tethys Bioscience and Xoma, and received lecture fees from Lilly and Novartis. We confirm that these affiliations do not alter the adherence to all the PLOS Genetics policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: IP WP RM RPB SAS PO NW TD CLi KDS ML LG VLy. Performed the experiments: WP RM RPB SAS PO NW TD KH. Analyzed the data: IP WP RM RPB SAS PA PO NBN NW TF AS AB VLa CO WX JLa AUJ YCC JLi JRO PAB JF SA TD EA JT CLe AK OH KH BFV HMK CLM VV MNW RJL KKO CLa AT RR JK CLi PK KDS VLy. Contributed reagents/materials/analysis tools: SAS PA PO NW AP ACS AM PN BI TT NJW MS EW TAL TMF PF MW JGE CLi EI ARS KDS ML LG VLy. Wrote the paper: IP WP RM RPB PO NW AB MIM CLi LG VLy.