About the Authors

Diana Andrea Fernandes de Abreu

Contributed equally to this work with: Diana Andrea Fernandes de Abreu, Antonio Caballero

Affiliation MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom

Antonio Caballero

Contributed equally to this work with: Diana Andrea Fernandes de Abreu, Antonio Caballero

Affiliation MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom

Pascal Fardel

Affiliations Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, Biozentrum, University of Basel, Basel, Basel, Switzerland

Nicholas Stroustrup

Affiliation Dept of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Zhunan Chen

Affiliation Dept of Organismic and Evolutionary Biology, The Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America

KyungHwa Lee

Current address: Department of Physiology, Pharmacology, and Neuroscience, The Sophie Davis School of Biomedical Education, City College of New York, New York, New York, United States of America.

Affiliation Lewis-Sigler Institute for Integrative Genomics and Dept of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

William D. Keyes

Affiliation Lewis-Sigler Institute for Integrative Genomics and Dept of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

Zachary M. Nash

Affiliation Dept of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Isaac F. López-Moyado

Affiliation Dept of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Federico Vaggi

Affiliation Research and Innovation Center, Fondazione Edmund Mach, San Michele all'Adige, Italy

Astrid Cornils

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Martin Regenass

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Anca Neagu

Affiliations Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, Biozentrum, University of Basel, Basel, Basel, Switzerland

Ivan Ostojic

Affiliation Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

Chang Liu

Affiliation MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom

Yongmin Cho

Affiliation School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Deniz Sifoglu

Affiliation Dept of Biological Sciences, Wayne State University, Detroit, Michigan, United States of America

Yu Shen

Affiliation Dept of Organismic and Evolutionary Biology, The Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America

Walter Fontana

Affiliation Dept of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Hang Lu

Affiliation School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Attila Csikasz-Nagy

Affiliations Research and Innovation Center, Fondazione Edmund Mach, San Michele all'Adige, Italy, Institute for Mathematical and Molecular Biomedicine, King's College London, London, United Kingdom, Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom

Coleen T. Murphy

Affiliation Lewis-Sigler Institute for Integrative Genomics and Dept of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America

Adam Antebi

Antebi@age.mpg.de (AA); eric.blanc@kcl.ac (EB); javier_apfeld@hms.harvard.edu (JAp); yzhang@oeb.harvard.edu (YZ); joy.alcedo@wayne.edu (JAl); queelim@kcl.ac.uk (QC)

Affiliation Max Planck Institute for Biology of Ageing, Koeln, Germany

Eric Blanc

Antebi@age.mpg.de (AA); eric.blanc@kcl.ac (EB); javier_apfeld@hms.harvard.edu (JAp); yzhang@oeb.harvard.edu (YZ); joy.alcedo@wayne.edu (JAl); queelim@kcl.ac.uk (QC)

Affiliation MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom

Javier Apfeld

Antebi@age.mpg.de (AA); eric.blanc@kcl.ac (EB); javier_apfeld@hms.harvard.edu (JAp); yzhang@oeb.harvard.edu (YZ); joy.alcedo@wayne.edu (JAl); queelim@kcl.ac.uk (QC)

Affiliation Dept of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Yun Zhang

Antebi@age.mpg.de (AA); eric.blanc@kcl.ac (EB); javier_apfeld@hms.harvard.edu (JAp); yzhang@oeb.harvard.edu (YZ); joy.alcedo@wayne.edu (JAl); queelim@kcl.ac.uk (QC)

Affiliation Dept of Organismic and Evolutionary Biology, The Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America

Joy Alcedo

Antebi@age.mpg.de (AA); eric.blanc@kcl.ac (EB); javier_apfeld@hms.harvard.edu (JAp); yzhang@oeb.harvard.edu (YZ); joy.alcedo@wayne.edu (JAl); queelim@kcl.ac.uk (QC)

Affiliations Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, Dept of Biological Sciences, Wayne State University, Detroit, Michigan, United States of America

QueeLim Ch'ng

Antebi@age.mpg.de (AA); eric.blanc@kcl.ac (EB); javier_apfeld@hms.harvard.edu (JAp); yzhang@oeb.harvard.edu (YZ); joy.alcedo@wayne.edu (JAl); queelim@kcl.ac.uk (QC)

Affiliation MRC Centre for Developmental Neurobiology, King's College London, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DAFdA ACa PF NS ZC KL ACo WF CTM AA JAp YZ JAl QC. Performed the experiments: DAFdA ACa PF NS ZC KL WDK ZMN IFLM ACo MR AN IO CL DS YS JAp JAl QC. Analyzed the data: DAFdA ACa PF NS ZC KL WDK FV ACo CL YC YS WF HL ACN CTM AA EB JAp YZ JAl QC. Contributed reagents/materials/analysis tools: DAFdA ACa PF NS ZC FV YC WF HL ACN EB JAp JAl QC. Wrote the paper: DAFdA ACa NS ZC FV HL ACN AA EB JAp YZ JAl QC. Coordinated the multi-lab study: QC.