About the Authors

Rico Rueedi

Contributed equally to this work with: Rico Rueedi, Mirko Ledda

Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

Mirko Ledda

Contributed equally to this work with: Rico Rueedi, Mirko Ledda

Affiliation Department of Food-Consumer Interaction, Nestlé Research Center, Lausanne, Switzerland

Andrew W. Nicholls

Affiliation Investigative Preclinical Toxicology, GlaxoSmithKline R&D, Ware, Herts, United Kingdom

Reza M. Salek

Affiliations European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Department of Biochemistry & Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom

Pedro Marques-Vidal

Affiliation Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland

Edgard Morya

Affiliations Sensonomic Laboratory of Alberto Santos Dumont Research Support Association and IEP Sirio, Libanes Hospital, São Paulo, Brazil, Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal, Brazil

Koichi Sameshima

Affiliation Department of Radiology and Oncology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

Ivan Montoliu

Affiliation Department of Bioanalytical Sciences, Nestlé Research Center, Lausanne, Switzerland

Laeticia Da Silva

Affiliation Department of Bioanalytical Sciences, Nestlé Research Center, Lausanne, Switzerland

Sebastiano Collino

Affiliation Department of Bioanalytical Sciences, Nestlé Research Center, Lausanne, Switzerland

François-Pierre Martin

Affiliation Department of Bioanalytical Sciences, Nestlé Research Center, Lausanne, Switzerland

Serge Rezzi

Affiliation Department of Bioanalytical Sciences, Nestlé Research Center, Lausanne, Switzerland

Christoph Steinbeck

Affiliation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Dawn M. Waterworth

Affiliation Medical Genetics, GlaxoSmithKline, Philadelphia, Pennsylvania, United States of America

Gérard Waeber

Affiliation Department of Medicine, Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

Peter Vollenweider

Affiliation Department of Medicine, Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

Jacques S. Beckmann

Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

Johannes Le Coutre

Affiliations Department of Food-Consumer Interaction, Nestlé Research Center, Lausanne, Switzerland, Organization for Interdisciplinary Research Projects, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan

Vincent Mooser

Affiliation Department of Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

Sven Bergmann

sven.bergmann@unil.ch

Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

Ulrich K. Genick

Affiliation Department of Food-Consumer Interaction, Nestlé Research Center, Lausanne, Switzerland

Zoltán Kutalik

Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland

Competing Interests

ML IM SC FPM SR JLC UKG are employees of Nestec SA, which has a commercial interest in the way humans metabolize food. AWN DMW VM are employees of GlaxoSmithKline, a pharmaceutical company. PV GW received financial support from GlaxoSmithKline to build the CoLaus study.

Author Contributions

Conceived and designed the experiments: KS EM PV GW. Performed the experiments: AWN VM DMW UKG ML EM LDS IM FPM SC SR. Analyzed the data: RR ML IM RMS UKG SB ZK. Contributed reagents/materials/analysis tools: PMV JLC CS UKG SR EM KS JSB SB ZK. Wrote the paper: RR ML JSB UKG ZK SB.