About the Authors

Bari J. Ballew

BJB, VJ and SD share first authorship.

Affiliation Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

Vijai Joseph

BJB, VJ and SD share first authorship.

Affiliation Clinical Genetics Service, Department of Medicine, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Saurav De

BJB, VJ and SD share first authorship.

Affiliation Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Grzegorz Sarek

Affiliation DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, South Mimms, United Kingdom

Jean-Baptiste Vannier

Affiliation DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, South Mimms, United Kingdom

Travis Stracker

Affiliation Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Kasmintan A. Schrader

Affiliation Clinical Genetics Service, Department of Medicine, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Trudy N. Small

Affiliation Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Richard O'Reilly

Affiliation Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Chris Manschreck

Affiliation Clinical Genetics Service, Department of Medicine, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Megan M. Harlan Fleischut

Affiliation Clinical Genetics Service, Department of Medicine, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Liying Zhang

Affiliation Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

John Sullivan

Affiliation Clinical Genetics Service, Department of Medicine, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Kelly Stratton

Affiliation Clinical Genetics Service, Department of Medicine, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Meredith Yeager

Affiliation Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

Kevin Jacobs

Affiliation Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

Neelam Giri

Affiliation Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

Blanche P. Alter

Affiliation Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

Joseph Boland

Affiliation Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

Laurie Burdett

Affiliation Cancer Genomics Research Laboratory, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America

Kenneth Offit

Affiliations Clinical Genetics Service, Department of Medicine, Memorial Hospital, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Cancer Genetics and Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Simon J. Boulton

Affiliation DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, South Mimms, United Kingdom

Sharon A. Savage

Contributed equally to this work with: Sharon A. Savage, John H. J. Petrini

savagesh@mail.nih.gov (SAS); petrinij@mskcc.org (JHJP)

Affiliation Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

John H. J. Petrini

Contributed equally to this work with: Sharon A. Savage, John H. J. Petrini

savagesh@mail.nih.gov (SAS); petrinij@mskcc.org (JHJP)

Affiliation Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SAS JHJP KO BJB VJ SD SJB. Performed the experiments: BJB VJ SD GS JBV TS KS MY KJ SJB LB TS CM KAS JB LZ. Analyzed the data: BJB SAS VJ SD GS JBV SJB JS KS JHJP JB. Contributed reagents/materials/analysis tools: NG BPA SAS JHJP KO. Wrote the paper: BJB SAS JHJP. Clinical Characterization of Patients: MMHF TNS RO BPA NG SAS.