About the Authors

Gang Li

Affiliation Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Dorothée Diogo

Affiliations Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

Di Wu

Affiliations Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America

Jim Spoonamore

Affiliation Chemical Biology Platform, Broad Institute, Cambridge, Massachusetts, United States of America

Vlado Dancik

Affiliation Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

Lude Franke

Affiliation Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands

Fina Kurreeman

Affiliations Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

Elizabeth J. Rossin

Affiliations Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America, Biological and Biomedical Sciences Program, Health Sciences and Technology Program, Harvard Medical School, Boston, Massachusetts, United States of America, Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Grant Duclos

Affiliation Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Cathy Hartland

Affiliation Chemical Biology Platform, Broad Institute, Cambridge, Massachusetts, United States of America

Xuezhong Zhou

Affiliation School of Computer and Information Technology, Beijing Jiaotong University, Beijing, China

Kejie Li

Affiliation Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

Jun Liu

Affiliation Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America

Philip L. De Jager

Affiliations Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America, Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Katherine A. Siminovitch

Affiliations Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Mount Sinai Hospital, Samuel Lunenfeld Research Institute and Toronto General Research Institute, Toronto, Ontario, Canada

Alexandra Zhernakova

Affiliations Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands, Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands

Soumya Raychaudhuri

Affiliations Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

John Bowes

Affiliations Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

Steve Eyre

Affiliations Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

Leonid Padyukov

Affiliation Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden

Peter K. Gregersen

Affiliation The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, New York, United States of America

Jane Worthington

Affiliations Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, United Kingdom

Rheumatoid Arthritis Consortium International (RACI)
Namrata Gupta

Affiliation Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

Paul A. Clemons

Affiliation Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

Eli Stahl

Affiliations Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

Nicola Tolliday

Affiliation Chemical Biology Platform, Broad Institute, Cambridge, Massachusetts, United States of America

Robert M. Plenge

rplenge@partners.org

Affiliations Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Medical and Population Genetics Program, Chemical Biology Program, Broad Institute, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GL DD DW JS VD LF FK EJR PAC NT RMP. Performed the experiments: GL DD DW JS VD LF FK EJR GD. Analyzed the data: GL DD DW JS VD LF FK EJR PAC ES NT RMP. Contributed reagents/materials/analysis tools: XZ KL JL PLDJ KAS AZ SR JB SE LP PKG JW NG. Wrote the paper: GL DD DW JS VD LF FK EJR GD CH XZ KL JL PLDJ KAS AZ SR JB SE LP PKG JW NG PAC ES NT RMP.