About the Authors

Li Liu

Affiliation Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

Aniko Sabo

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Benjamin M. Neale

Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Uma Nagaswamy

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Christine Stevens

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Elaine Lim

Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Corneliu A. Bodea

Affiliation Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

Donna Muzny

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Jeffrey G. Reid

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Eric Banks

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Hillary Coon

Affiliation Department of Psychiatry, University of Utah, Salt Lake City, Utah, United States of America

Mark DePristo

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Huyen Dinh

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Tim Fennel

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Jason Flannick

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Stacey Gabriel

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Kiran Garimella

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Shannon Gross

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Alicia Hawes

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Lora Lewis

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Vladimir Makarov

Affiliations Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

Jared Maguire

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Irene Newsham

Affiliation University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Ryan Poplin

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Stephan Ripke

Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Khalid Shakir

Affiliation Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Kaitlin E. Samocha

Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Yuanqing Wu

Affiliation University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Eric Boerwinkle

Affiliations Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Joseph D. Buxbaum

Affiliations Seaver Autism Center for Research and Treatment, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York United States of America

Edwin H. Cook Jr

Affiliation Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, United States of America

Bernie Devlin

Affiliation Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Gerard D. Schellenberg

Affiliation Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

James S. Sutcliffe

Affiliation Vanderbilt Brain Institute, Department of Molecular Physiology and Biophysics and Department of Psychiatry, Vanderbilt University, Nashville, Tennessee, United States of America

Mark J. Daly

Affiliations Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Richard A. Gibbs

Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America

Kathryn Roeder

roeder@stat.cmu.edu

Affiliations Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America, Ray and Stephanie Lane Center for Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: E Boerwinkle, RA Gibbs, EH Cook, JD Buxbaum, K Roeder, B Devlin, GD Schellenberg, JS Sutcliffe, MJ Daly. Performed the experiments: A Sabo, U Nagaswamy, C Stevens, D Muzny, JG Reid, S Gabriel, E Banks, H Dinh, A Hawes, L Lewis, I Newsham, Y Wu. Analyzed the data: L Liu, BM Neale, A Sabo, U Nagaswamy, C Stevens, E Lim, CA Bodea, J Maguire, KE Samocha, B Devlin, MJ Daly, K Roeder. Contributed reagents/materials/analysis tools: H Coon. Wrote the paper: L Liu, K Roeder, B Devlin. Data processing: A Sabo, BM Neale, U Nagaswamy, C Stevens, E Lim, KE Samocha, M DePristo, T Fennel, J Flannick, S Gross, K Garimella, S Gabriel, V Makarov, R Poplin, S Ripke, K Shakir. Statistical methods: L Liu, K Roeder.