The Environment Affects Epistatic Interactions to Alter the Topology of an Empirical Fitness Landscape

Kenneth M. Flynn; Tim F. Cooper; Francisco B-G. Moore; Vaughn S. Cooper

doi:10.1371/journal.pgen.1003426

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Open Access

Peer-reviewed

Research Article

The Environment Affects Epistatic Interactions to Alter the Topology of an Empirical Fitness Landscape

Kenneth M. Flynn,

Affiliation Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, United States of America
⨯
Tim F. Cooper,

Affiliation Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States of America
⨯
Francisco B-G. Moore,

Affiliation Integrated Bioscience Program, University of Akron, Akron, Ohio, United States of America
⨯
Vaughn S. Cooper

* E-mail: vaughn.cooper@unh.edu

Affiliation Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, United States of America
⨯

The Environment Affects Epistatic Interactions to Alter the Topology of an Empirical Fitness Landscape

Kenneth M. Flynn,
Tim F. Cooper,
Francisco B-G. Moore,
Vaughn S. Cooper

Published: April 4, 2013
https://doi.org/10.1371/journal.pgen.1003426

About the Authors

Kenneth M. Flynn

Affiliation Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, United States of America

Tim F. Cooper

Affiliation Department of Biology and Biochemistry, University of Houston, Houston, Texas, United States of America

Francisco B-G. Moore

Affiliation Integrated Bioscience Program, University of Akron, Akron, Ohio, United States of America

Vaughn S. Cooper

* E-mail: vaughn.cooper@unh.edu

Affiliation Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KMF TFC FB-GM VSC. Performed the experiments: KMF. Analyzed the data: KMF TFC FB-GM VSC. Contributed reagents/materials/analysis tools: KMF TFC FB-GM VSC. Wrote the paper: KMF TFC VSC.

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Fitness epistasis
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Insertion mutation
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Natural selection
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Glucose
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Deletion mutation
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Evolutionary genetics
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Substitution mutation
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Bacterial evolution
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