About the Authors
- Ying Wu
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Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Lindsay L. Waite
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Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America
- Anne U. Jackson
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Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
- Wayne H-H. Sheu
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Affiliations Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, School of Medicine, National Yang-Ming University, Taipei, Taiwan, College of Medicine, National Defense Medical Center, Taipei, Taiwan
- Steven Buyske
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Affiliation Department of Statistics and Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America
- Devin Absher
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Affiliation HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America
- Donna K. Arnett
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Affiliation Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
- Eric Boerwinkle
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Affiliation The Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America
- Lori L. Bonnycastle
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Affiliation Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Cara L. Carty
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Affiliation Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
- Iona Cheng
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Affiliation University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
- Barbara Cochran
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Affiliation The Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America
- Damien C. Croteau-Chonka
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Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Logan Dumitrescu
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Affiliation Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
- Charles B. Eaton
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Affiliation Departments of Family Medicine and Epidemiology, Alpert Medical School, Brown University, Providence, Rhode Island, United States of America
- Nora Franceschini
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Affiliation Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Xiuqing Guo
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Brian E. Henderson
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Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Lucia A. Hindorff
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Affiliation Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Eric Kim
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Leena Kinnunen
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Affiliation Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
- Pirjo Komulainen
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Affiliation Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
- Wen-Jane Lee
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Affiliation Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
- Loic Le Marchand
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Affiliation University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
- Yi Lin
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Affiliation Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
- Jaana Lindström
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Affiliation Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
- Oddgeir Lingaas-Holmen
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Affiliation HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway
- Sabrina L. Mitchell
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Affiliation Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
- Narisu Narisu
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Affiliation Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Jennifer G. Robinson
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Affiliation University of Iowa, Iowa City, Iowa, United States of America
- Fred Schumacher
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Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Alena Stančáková
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Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
- Jouko Sundvall
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Affiliation National Institute for Health and Welfare, Disease Risk Unit, Helsinki, Finland
- Yun-Ju Sung
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Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America
- Amy J. Swift
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Affiliation Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Wen-Chang Wang
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Affiliation Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
- Lynne Wilkens
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Affiliation University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
- Tom Wilsgaard
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Affiliation Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
- Alicia M. Young
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Affiliation Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
- Linda S. Adair
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Affiliation Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Christie M. Ballantyne
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Affiliation Baylor College of Medicine, Houston, Texas, United States of America
- Petra Bůžková
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Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
- Aravinda Chakravarti
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Affiliation Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
- Francis S. Collins
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Affiliation Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- David Duggan
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Affiliation Translational Genomics Research Institute, Phoenix, Arizona, United States of America
- Alan B. Feranil
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Affiliation Office of Population Studies Foundation, University of San Carlos, Cebu, Philippines
- Low-Tone Ho
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Affiliations School of Medicine, National Yang-Ming University, Taipei, Taiwan, Department of Internal Medicine and Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan
- Yi-Jen Hung
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Affiliation Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
- Steven C. Hunt
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Affiliation Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States of America
- Kristian Hveem
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Affiliation HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway
- Jyh-Ming J. Juang
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Affiliation Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
- Antero Y. Kesäniemi
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Affiliation Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland
- Johanna Kuusisto
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Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
- Markku Laakso
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Affiliation Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
- Timo A. Lakka
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Affiliations Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
- I-Te Lee
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Affiliations Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Mark F. Leppert
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Affiliation Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
- Tara C. Matise
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Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America
- Leena Moilanen
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Affiliations Department of Medicine, Kuopio University Hospital, Kuopio, Finland, Pirkanmaa Hospital District, Tampere, Finland
- Inger Njølstad
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Affiliation Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
- Ulrike Peters
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Affiliations Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, School of Public Health, University of Washington, Seattle, Washington, United States of America
- Thomas Quertermous
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Affiliation Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America
- Rainer Rauramaa
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Affiliations Kuopio Research Institute of Exercise Medicine, Kuopio, Finland, Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
- Jerome I. Rotter
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Jouko Saramies
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Affiliation South Karelia Central Hospital, Lappeenranta, Finland
- Jaakko Tuomilehto
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Affiliations Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland, South Ostrobothnia Central Hospital, Seinäjoki, Finland, Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain, Centre for Vascular Prevention, Danube-University Krems, Krems, Austria
- Matti Uusitupa
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Affiliations Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland, Research Unit, Kuopio University Hospital, Kuopio, Finland
- Tzung-Dau Wang
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Affiliation Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
- Michael Boehnke
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Contributed equally to this work with: Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North
¶These authors were joint senior authors on this work.
Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
- Christopher A. Haiman
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Contributed equally to this work with: Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North
¶These authors were joint senior authors on this work.
Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
- Yii-Der I. Chen
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Contributed equally to this work with: Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North
¶These authors were joint senior authors on this work.
Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Charles Kooperberg
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Contributed equally to this work with: Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North
¶These authors were joint senior authors on this work.
Affiliation Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
- Themistocles L. Assimes
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Contributed equally to this work with: Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North
¶These authors were joint senior authors on this work.
Affiliation Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America
- Dana C. Crawford
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Contributed equally to this work with: Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North
¶These authors were joint senior authors on this work.
Affiliation Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
- Chao A. Hsiung
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Contributed equally to this work with: Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North
¶These authors were joint senior authors on this work.
Affiliation Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
- Kari E. North
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Contributed equally to this work with: Michael Boehnke, Christopher A. Haiman, Yii-Der I. Chen, Charles Kooperberg, Themistocles L. Assimes, Dana C. Crawford, Chao A. Hsiung, Kari E. North
¶These authors were joint senior authors on this work.
Affiliations Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Karen L. Mohlke
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* E-mail: mohlke@med.unc.edu
¶These authors were joint senior authors on this work.
Affiliations Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: Y Wu, KE North, KL Mohlke. Analyzed the data: Y Wu, LL Waite, AU Jackson, S Buyske. Drafted the manuscript: Y Wu. Provided analytic advice: M Boehnke, CA Haiman, C Kooperberg, TL Assimes, DC Crawford, KE North, KL Mohlke. Revised the manuscript: DK Arnett, LL Bonnycastle, S Buyske, CL Carty, I Cheng, L Dumitrescu, CB Eaton, N Franceschini, LA Hindorff, SL Mitchell, N Narisu, U Peters, JI Rotter, T-D Wang, M Boehnke, CA Haiman, Y-DI Chen, C Kooperberg, TL Assimes, DC Crawford, CA Hsiung, KE North, KL Mohlke. Management and design of studies contributing to this project: LS Adair, TL Assimes, CM Ballantyne, M Boehnke, P Buzkova, A Chakravarti, Y-DI Chen, FS Collins, D Duggan, AB Feranil, CA Haiman, L-T Ho, CA Hsiung, Y-J Hung, SC Hunt, K Hveem, J-MJ Juang, AY Kesäniemi, C Kooperberg, J Kuusisto, M Laakso, TA Lakka, I-T Lee, W-J Lee, MF Leppert, TC Matise, KL Mohlke, L Moilanen, I Njølstad, KE North, U Peters, T Quertermous, R Rauramaa, JI Rotter, J Saramies, WH-H Sheu, J Tuomilehto, M Uusitupa, T-D Wang. Sample collection and phenotyping of studies contributing to this project: LS Adair, DK Arnett, CM Ballantyne, Y-DI Chen, CB Eaton, AB Feranil, BE Henderson, L-T Ho, CA Hsiung, SC Hunt, J-MJ Juang, E Kim, L Kinnunen, P Komulainen, C Kooperberg, I-T Lee, W-J Lee, L Le Marchand, MF Leppert, J Lindström, KE North, JG Robinson, F Schumacher, WH-H Sheu, A Stančáková, J Sundvall, T-D Wang, L Wilkens, T Wilsgaard. Genotyping of studies contributing to this project: D Absher, TL Assimes, E Boerwinkle, LL Bonnycastle, S Buyske, A Chakravarti, Y-DI Chen, B Cochran, DC Croteau-Chonka, D Duggan, CA Haiman, E Kim, MF Leppert, O LingaasHolmen, N Narisu, T Quertermous, JI Rotter, AJ Swift. Statistical analysis of studies contributing to this project: D Absher, TL Assimes, S Buyske, P Buzkova, CL Carty, I Cheng, DC Crawford, L Dumitrescu, N Franceschini, X Guo, LA Hindorff, AU Jackson, C Kooperberg, Y Lin, SL Mitchell, KE North, U Peters, JI Rotter, Y-J Sung, LL Waite, W-C Wang, Y Wu, AM Young.