About the Authors

Daniel J. Gaffney

Contributed equally to this work with: Daniel J. Gaffney, Graham McVicker

dg13@sanger.ac.uk (DJG); gmcvicker@uchicago.edu (GM); gilad@uchicago.edu (YG); pritch@uchicago.edu (JKP)

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Graham McVicker

Contributed equally to this work with: Daniel J. Gaffney, Graham McVicker

dg13@sanger.ac.uk (DJG); gmcvicker@uchicago.edu (GM); gilad@uchicago.edu (YG); pritch@uchicago.edu (JKP)

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Athma A. Pai

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Yvonne N. Fondufe-Mittendorf

Affiliations Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Chicago, Illinois, United States of America, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America

Noah Lewellen

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Katelyn Michelini

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Jonathan Widom

† Deceased.

Affiliation Department of Molecular Biosciences and Department of Chemistry, Northwestern University, Chicago, Illinois, United States of America

Yoav Gilad

dg13@sanger.ac.uk (DJG); gmcvicker@uchicago.edu (GM); gilad@uchicago.edu (YG); pritch@uchicago.edu (JKP)

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Jonathan K. Pritchard

dg13@sanger.ac.uk (DJG); gmcvicker@uchicago.edu (GM); gilad@uchicago.edu (YG); pritch@uchicago.edu (JKP)

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJG GM YG JKP. Performed the experiments: AAP YNF-M KM NL. Analyzed the data: GM DJG. Wrote the paper: GM DJG JKP YG. Developed the paired-end MNase-seq protocol: JW YNF-M. Provided valuable advice at the onset of the project: JW. Supervised the project: YG JKP.