About the Authors
- Claudia Kutter
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Contributed equally to this work with: Claudia Kutter, Stephen Watt
Affiliations Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom, University of Cambridge, Cambridge, United Kingdom
- Stephen Watt
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Contributed equally to this work with: Claudia Kutter, Stephen Watt
Affiliation Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
- Klara Stefflova
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Affiliations Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom, University of Cambridge, Cambridge, United Kingdom
- Michael D. Wilson
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Current address: SickKids Research Institute and Department of Molecular Genetics, University of Toronto, Toronto, Canada
Affiliations Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom, University of Cambridge, Cambridge, United Kingdom
- Angela Goncalves
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Affiliations University of Cambridge, Cambridge, United Kingdom, European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, United Kingdom
- Chris P. Ponting
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* E-mail: chris.ponting@dpag.ox.ac.uk (CPP); duncan.odom@cancer.org.uk (DTO); ana.marques@dpag.ox.ac.uk (ACM)
¶These authors also contributed equally to this work.
Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
- Duncan T. Odom
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* E-mail: chris.ponting@dpag.ox.ac.uk (CPP); duncan.odom@cancer.org.uk (DTO); ana.marques@dpag.ox.ac.uk (ACM)
¶These authors also contributed equally to this work.
Affiliations Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
- Ana C. Marques
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* E-mail: chris.ponting@dpag.ox.ac.uk (CPP); duncan.odom@cancer.org.uk (DTO); ana.marques@dpag.ox.ac.uk (ACM)
¶These authors also contributed equally to this work.
Affiliation Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: CK SW CPP DTO ACM. Performed the experiments: CK SW KS MDW AG ACM. Analyzed the data: CK SW ACM. Wrote the paper: CK SW CPP DTO ACM. Designed the experiments: CK SW DTO. Performed RNAseq and ChIPseq experiments: CK SW KS MDW. Processed and mapped the reads: SW AG ACM. Assembled and annotated transcripts: SW ACM. Performed qPCR and RT–PCR validations: CK SW. Estimated the transcriptional turnover of lncRNAs: CK SW ACM. Performed genome enrichments and sequence constraint analysis of intergenic lncRNAs: ACM. Analysed the effect of lineage specific gene expression on neighbouring genes: ACM. Supervised the study: DTO CPP.