About the Authors

Tara A. Gianoulis

Contributed equally to this work with: Tara A. Gianoulis, Meghan A. Griffin, Daniel J. Spakowicz

† Deceased.

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts, United States of America, Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America

Meghan A. Griffin

Contributed equally to this work with: Tara A. Gianoulis, Meghan A. Griffin, Daniel J. Spakowicz

Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Daniel J. Spakowicz

Contributed equally to this work with: Tara A. Gianoulis, Meghan A. Griffin, Daniel J. Spakowicz

Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Brian F. Dunican

Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Cambria J. Alpha

Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Andrea Sboner

Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

A. Michael Sismour

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts, United States of America

Chinnappa Kodira

Affiliation Roche 454 Life Sciences, Branford, Connecticut, United States of America

Michael Egholm

Affiliation Pall Corporation, Long Island City, New York, United States of America

George M. Church

Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Wyss Institute for Biologically Inspired Engineering, Boston, Massachusetts, United States of America

Mark B. Gerstein

mark.gerstein@yale.edu (MBG); scott.strobel@yale.edu (SAS)

Affiliations Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Scott A. Strobel

mark.gerstein@yale.edu (MBG); scott.strobel@yale.edu (SAS)

Affiliation Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America

Competing Interests

CK currently works at 454 Life Sciences. All of the work reported in this manuscript was completed when he was in residence at the Broad Institute. ME currently works at Pall Corporation. All of the work reported in this manuscript was completed when he was at 454 Life Sciences..

Author Contributions

Conceived and designed the experiments: TAG MAG DJS CJA BFD MBG SAS. Performed the experiments: TAG MAG DJS CJA BFD. Analyzed the data: TAG MAG DJS CJA BFD AS. Wrote the paper: TAG MAG DJS. Performed initial genome sequencing and assembly: CK ME. Contributed to the pathway trajectory analysis: AMS GMC.