About the Authors

Deborah S. Cunninghame Graham

Affiliations Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, School of Medicine, King's College London, London, United Kingdom, Academic Department of Rheumatology, Division of Immunology, Infection, and Inflammatory Diseases, School of Medicine, King's College London, London, United Kingdom

David L. Morris

Affiliations Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, School of Medicine, King's College London, London, United Kingdom, Academic Department of Rheumatology, Division of Immunology, Infection, and Inflammatory Diseases, School of Medicine, King's College London, London, United Kingdom

Tushar R. Bhangale

Affiliation Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, California, United States of America

Lindsey A. Criswell

Affiliation Rosalind Russell Medical Research Center for Arthritis, Division of Rheumatology, University of California San Francisco, San Francisco, California, United States of America

Ann-Christine Syvänen

Affiliation Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

Lars Rönnblom

Affiliation Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

Timothy W. Behrens

Affiliation ITGR Human Genetics Group, Genentech, San Francisco, California, United States of America

Robert R. Graham

Affiliation ITGR Human Genetics Group, Genentech, San Francisco, California, United States of America

Timothy J. Vyse

timothy.vyse@kcl.ac.uk

Affiliations Department of Medical and Molecular Genetics, Division of Genetics and Molecular Medicine, School of Medicine, King's College London, London, United Kingdom, Academic Department of Rheumatology, Division of Immunology, Infection, and Inflammatory Diseases, School of Medicine, King's College London, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DSCG RRG. Performed the experiments: DSCG TRB. Analyzed the data: DSCG DLM TRB RRG. Contributed reagents/materials/analysis tools: LAC A-CS LR TWB TJV. Wrote the paper: DSCG RRG TWB TJV. Constructive comments on the manuscript: LAC A-CS LR. Generated the genotype data for the published US data: TRB. Oversaw the genotyping of the Swedish samples at the SNP&SEQ technology platform in Uppsala for the previous publication: A-CS. Supervised the data generation and statistical analysis for the out-of-study US/SWE dataset: RRG. Provided the funding and scientific oversight for the out-of-study US/SWE dataset: TWB. Provided the funding and overall scientific oversight for the study: TJV.