About the Authors

Ching-Ti Liu

Contributed equally to this work with: Ching-Ti Liu, Maija K. Garnaas

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Maija K. Garnaas

Contributed equally to this work with: Ching-Ti Liu, Maija K. Garnaas

Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

Adrienne Tin

Affiliation Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

Anna Kottgen

Affiliations Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Renal Division, University Hospital of Freiburg, Freiburg, Germany

Nora Franceschini

Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Carmen A. Peralta

Affiliation Division of Nephrology, University of California San Francisco Medical School and San Francisco VA Medical Center, San Francisco, California, United States of America

Ian H. de Boer

Affiliation Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, United States of America

Xiaoning Lu

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Elizabeth Atkinson

Affiliation Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

Jingzhong Ding

Affiliation Gerontology and Geriatric Medicine, J. Paul Sticht Center on Aging, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

Michael Nalls

Affiliation Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Daniel Shriner

Affiliation Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America

Josef Coresh

Affiliation Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

Abdullah Kutlar

Affiliation Medical College of Georgia, Augusta, Georgia, United States of America

Kirsten Bibbins-Domingo

Affiliation University of California San Francisco, San Francisco, California, United States of America

David Siscovick

Affiliation Cardiovascular Health Research Unit, Departments of Epidemiology and Medicine, University of Washington, Seattle, Washington, United States of America

Ermeg Akylbekova

Affiliation Jackson State University, Jackson, Mississippi, United States of America

Sharon Wyatt

Affiliation School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Brad Astor

Affiliation Department of Epidemiology, Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Josef Mychaleckjy

Affiliation Center for Public Health Genomics, Charlottesville, Virginia, United States of America

Man Li

Affiliation Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America

Muredach P. Reilly

Affiliation Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Raymond R. Townsend

Affiliation Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Adebowale Adeyemo

Affiliation Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America

Alan B. Zonderman

Affiliation Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Mariza de Andrade

Affiliation Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

Stephen T. Turner

Affiliation Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America

Thomas H. Mosley

Affiliation Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Tamara B. Harris

Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

The CKDGen Consortium
Charles N. Rotimi

Affiliation Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America

Yongmei Liu

Affiliation Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States of America

Sharon L. R. Kardia

Affiliation Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America

Michele K. Evans

Affiliation Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Michael G. Shlipak

Affiliation General Internal Medicine, University of California San Francisco, San Francisco, California, United States of America

Holly Kramer

Affiliation Loyola University, Maywood, Illinois, United States of America

Michael F. Flessner

Affiliation Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Albert W. Dreisbach

Affiliation University of Mississippi Division of Nephrology, University of Mississippi, Jackson, Mississippi, United States of America

Wolfram Goessling

foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WLK); wgoessling@partners.org (WG)

Affiliations Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America, Divisions of Genetics and Gastroenterology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

L. Adrienne Cupples

These authors were joint senior authors on this work.

Affiliation Department of Biostatistics, Boston University School of Public Health and National Heart, Blood, and Lung Institute's Framingham Heart Study, Boston, Massachusetts, United States of America

W. Linda Kao

foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WLK); wgoessling@partners.org (WG)

Affiliation Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

Caroline S. Fox

foxca@nhlbi.nih.gov (CSF); wkao@jhsph.edu (WLK); wgoessling@partners.org (WG)

Affiliations National Heart, Blood, and Lung Institute's Framingham Heart Study and the Center for Population Studies, Framingham, Massachusetts, United States of America, Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, Y Liu, TB Harris, J Ding, SLR Kardia, WL Kao, CS Fox. Performed the experiments: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, Y Liu, TB Harris, J Ding, SLR Kardia, ST Turner, J Coresh, D Shriner, MG Shlipak, H Kramer, AW Dreisbach, WL Kao, CS Fox. Analyzed the data: A Adeyemo, D Shriner, AB Zonderman, M Nalls, Y Liu, TB Harris, J Ding, SLR Kardia, M de Andrade, ST Turner, E Akylbekova, MF Flessner, C-T Liu, A Tin, A Kottgen, N Francheschini, CA Peralta, IH de Boer, X Lu, M Li, AW Dreisbach, LA Cupples, WL Kao, CS Fox. Wrote the paper: SLR Kardia, MF Flessner, MK Garnaas, W Goessling, C-T Liu, A Tin, A Kottgen, N Francheschini, CA Peralta, IH de Boer, LA Cupples, WL Kao, CS Fox. Subject recruitment: A Adeyemo, CN Rotimi, MK Evans, AB Zonderman, TB Harris, ST Turner, J Coresh,, D Siscovick, WL Kao, CS Fox. Critical review of manuscript: CS Fox C-T Liu, MK Garnaas, A Tin, A Kottgen, N Franceschini, CA Peralta, IH de Boer, X Lu, E Atkinson, J Ding, M Nalls, D Shriner, J Coresh, A Kutlar, K Bibbins-Domingo, D Siscovick, E Akylbekova, S Wyatt, B Astor, J Mychaleckjy, M Li, MP Reilly, RR Townsend, A Adeyemo, AB Zonderman, M de Andrade, ST Turner, TH Mosley, TB Harris, CKDGen Consortium, CN Rotimi, Y Liu, SLR Kardia, MK Evans, MG Shlipak, H Kramer, MF Flessner, AW Dreisbach, W Goessling, LA Cupples, WL Kao. Statistical methods and analysis: A Adeyemo, D Shriner, M Nalls, Y Liu, J Ding, M de Andrade, E Akylbekova, SLR Kardia, MK Garnaas, W Goessling, C-T Liu, A Tin, A Kottgen, X Lu, E Atkinson, M Li, LA Cupples WL Kao, CS Fox. Genotyping: A Adeyemo, D Shriner, M Nalls, Y Liu, M de Andrade, LA Cupples, WL Kao. Bioinformatics: M Nalls, C-T Liu. Zebrafish Work: MK Garnaas, W Goessling. Study management: D Siscovick.