Distinct Functional Constraints Partition Sequence Conservation in a cis-Regulatory Element

Antoine Barrière; Kacy L. Gordon; Ilya Ruvinsky

doi:10.1371/journal.pgen.1002095

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Open Access

Peer-reviewed

Research Article

Distinct Functional Constraints Partition Sequence Conservation in a cis-Regulatory Element

Antoine Barrière ,

Contributed equally to this work with: Antoine Barrière, Kacy L. Gordon

Affiliation Department of Ecology and Evolution and Institute for Genomics and Systems Biology, Chicago, Illinois, United States of America
⨯
Kacy L. Gordon ,

Contributed equally to this work with: Antoine Barrière, Kacy L. Gordon

Affiliation Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois, United States of America
⨯
Ilya Ruvinsky

* E-mail: ruvinsky@uchicago.com

Affiliations Department of Ecology and Evolution and Institute for Genomics and Systems Biology, Chicago, Illinois, United States of America, Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois, United States of America
⨯

Distinct Functional Constraints Partition Sequence Conservation in a cis-Regulatory Element

Antoine Barrière,
Kacy L. Gordon,
Ilya Ruvinsky

Published: June 2, 2011
https://doi.org/10.1371/journal.pgen.1002095

About the Authors

Antoine Barrière

Contributed equally to this work with: Antoine Barrière, Kacy L. Gordon

Affiliation Department of Ecology and Evolution and Institute for Genomics and Systems Biology, Chicago, Illinois, United States of America

Kacy L. Gordon

Contributed equally to this work with: Antoine Barrière, Kacy L. Gordon

Affiliation Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois, United States of America

Ilya Ruvinsky

* E-mail: ruvinsky@uchicago.com

Affiliations Department of Ecology and Evolution and Institute for Genomics and Systems Biology, Chicago, Illinois, United States of America, Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB KLG IR. Performed the experiments: AB KLG. Analyzed the data: AB KLG IR. Wrote the paper: AB KLG IR.

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Caenorhabditis elegans
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Neurons
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Gene expression
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Nucleosomes
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Invertebrate genomics
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Nucleotide sequencing
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Sequence motif analysis
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