About the Authors

Lễ B. Nguyễn

Affiliations Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Genomics and Computational Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Sharon J. Diskin

Affiliation Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Mario Capasso

Affiliations Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Naples, Italy, CEINGE Biotecnologie Avanzate, Naples, Italy

Kai Wang

Affiliation The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Maura A. Diamond

Affiliation Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Joseph Glessner

Affiliation The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Cecilia Kim

Affiliation The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Edward F. Attiyeh

Affiliations Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Yael P. Mosse

Affiliations Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Kristina Cole

Affiliations Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Achille Iolascon

Affiliations Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Naples, Italy, CEINGE Biotecnologie Avanzate, Naples, Italy

Marcella Devoto

Affiliation Division of Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Hakon Hakonarson

Affiliations The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Division of Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Hongzhe K. Li

Affiliation Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

John M. Maris

Maris@email.chop.edu

Affiliations Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Genomics and Computational Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, CEINGE Biotecnologie Avanzate, Naples, Italy, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed analyses: LBN KW MD HH HKL JMM. Performed genotyping and validation: LBN SJD MC MD JG CK EFA YPM KC AI. Conceived and designed the experiments: JMM LBN HKL SJD HH MC. Performed the experiments: LBN SJD MC KW MAD JG CK EFA YPM KC AI MD HH HKL JMM. Analyzed the data: LBN SJD MC KW MAD JG CK EFA YPM KC AI MD HH HKL JMM. Contributed reagents/materials/analysis tools: JMM HH MC AI. Wrote the paper: LBN SJD HH HKL JMM.