About the Authors

Benjamin M. Neale

Contributed equally to this work with: Benjamin M. Neale, Manuel A. Rivas

bneale@broadinstitute.org(BMN); mjdaly@chgr.mgh.harvard.edu(MJD); Kathryn.roeder@gmail.com (KR)

Affiliations The Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Manuel A. Rivas

Contributed equally to this work with: Benjamin M. Neale, Manuel A. Rivas

Affiliations The Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Benjamin F. Voight

Affiliations The Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

David Altshuler

Affiliations The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Bernie Devlin

Affiliation Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Marju Orho-Melander

Affiliation Department of Clinical Sciences Malmö, Diabetes and Cardiovascular Diseases, Genetic Epidemiology CRC, University Hospital Malmö, Malmö, Sweden

Sekar Kathiresan

Affiliations The Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Shaun M. Purcell

Affiliations The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Kathryn Roeder

bneale@broadinstitute.org(BMN); mjdaly@chgr.mgh.harvard.edu(MJD); Kathryn.roeder@gmail.com (KR)

These authors also contributed equally to this work.

Affiliation Department of Statistics, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

Mark J. Daly

bneale@broadinstitute.org(BMN); mjdaly@chgr.mgh.harvard.edu(MJD); Kathryn.roeder@gmail.com (KR)

These authors also contributed equally to this work.

Affiliations The Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BMN MAR BFV DA BD SMP KR MJD. Performed the experiments: BMN MAR KR MJD. Analyzed the data: BMN MAR KR MJD. Contributed reagents/materials/analysis tools: BMN MAR MOM SK SMP KR MJD. Wrote the paper: BMN MAR KR MJD. Commented on the manuscript and aided in the development of the method: BFV BD. Commented on the manuscript and aided in the development of the methodological idea: DA. Contributed APOB data: MOM SK.