About the Authors

Mia M. Gaudet

Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn

Affiliation Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York, United States of America

Tomas Kirchhoff

Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn

Affiliations Clinical Genetics Service, Department of Medicine, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Todd Green

Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America

Joseph Vijai

Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn

Affiliation Clinical Genetics Service, Department of Medicine, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Joshua M. Korn

Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America

Candace Guiducci

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America

Ayellet V. Segrè

Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Kate McGee

Affiliation Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute – Frederick, Frederick, Maryland, United States of America

Lesley McGuffog

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Christiana Kartsonaki

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Jonathan Morrison

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Sue Healey

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Olga M. Sinilnikova

Affiliations Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France, Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France

Dominique Stoppa-Lyonnet

Affiliations Institut Curie, Service de Génétique, INSERM U830, F-75248, Université Paris Descartes, Paris, France, Service de Genetique Oncologique, Institut Curie, Paris, France

Sylvie Mazoyer

Affiliation Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France

Marion Gauthier-Villars

Affiliation Service de Genetique Oncologique, Institut Curie, Paris, France

Hagay Sobol

Affiliation Département Oncologie génétique, Prévention et Dépistage, INSERM CIC-P9502, Institut Paoli-Calmettes/Université d'Aix-Marseille II, Marseille, France

Michel Longy

Affiliation Institut Bergonié, Bordeaux, France

Marc Frenay

Affiliation Centre Antoine Lacassagne, Nice, France

GEMO Study Collaborators

Membership of each consortium is provided in the Acknowledgements.

Affiliation GEMO Study - Cancer Genetics Network “Groupe Génétique et Cancer”, Fédération Nationale des Centres de Lutte Contre le Cancer, Paris, France

Frans B. L. Hogervorst

Affiliation Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands

Matti A. Rookus

Affiliation Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands

J. Margriet Collée

Affiliation Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands

Nicoline Hoogerbrugge

Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Kees E. P. van Roozendaal

Affiliation Department of Clinical Genetics, University Medical Center, Maastricht, The Netherlands

HEBON Study Collaborators

Membership of each consortium is provided in the Acknowledgements.

Affiliation Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands

Marion Piedmonte

Affiliation Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America

Wendy Rubinstein

Affiliation NorthShore University Health System, Evanston, Illinois, United States of America

Stacy Nerenstone

Affiliation Central Connecticut Cancer Consortium, Hartford Hospital, Hartford, Connecticut, United States of America

Linda Van Le

Affiliation University of North Carolina, Chapel Hill, North Carolina, United States of America

Stephanie V. Blank

Affiliation New York University School of Medicine, New York, New York, United States of America

Trinidad Caldés

Affiliation Molecular Oncology Laboratory, Hospital Clinico San Carlos, Madrid, Spain

Miguel de la Hoya

Affiliation Molecular Oncology Laboratory, Hospital Clinico San Carlos, Madrid, Spain

Heli Nevanlinna

Affiliation Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

Kristiina Aittomäki

Affiliation Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland

Conxi Lazaro

Affiliation Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain

Ignacio Blanco

Affiliation Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain

Adalgeir Arason

Affiliations Department of Oncology, Landspitali–LSH, Reykjavik, Iceland, Department of Pathology, Landspitali–LSH, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Oskar T. Johannsson

Affiliations Department of Oncology, Landspitali–LSH, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Rosa B. Barkardottir

Affiliations Department of Oncology, Landspitali–LSH, Reykjavik, Iceland, Department of Pathology, Landspitali–LSH, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland

Peter Devilee

Affiliation Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

Olofunmilayo I. Olopade

Affiliation Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, United States of America

Susan L. Neuhausen

Affiliation Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, California, United States of America

Xianshu Wang

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

Zachary S. Fredericksen

Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Paolo Peterlongo

Affiliations Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

Siranoush Manoukian

Affiliation Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy

Monica Barile

Affiliation Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy

Alessandra Viel

Affiliation Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy

Paolo Radice

Affiliation IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

Catherine M. Phelan

Affiliation Moffitt Cancer Center, Tampa, Florida, United States of America

Steven Narod

Affiliation Women's College Research Institute, Toronto, Canada

Gad Rennert

Affiliation CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel

Flavio Lejbkowicz

Affiliation CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel

Anath Flugelman

Affiliation CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel

Irene L. Andrulis

Affiliations Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Cancer Care Ontario, Ontario Cancer Genetics Network, University of Toronto, Toronto, Canada

Gord Glendon

Affiliation Cancer Care Ontario, Ontario Cancer Genetics Network, University of Toronto, Toronto, Canada

Hilmi Ozcelik

Affiliations Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Cancer Care Ontario, Ontario Cancer Genetics Network, University of Toronto, Toronto, Canada

OCGN

Membership of each consortium is provided in the Acknowledgements.

Affiliation Cancer Care Ontario, Ontario Cancer Genetics Network, University of Toronto, Toronto, Canada

Amanda E. Toland

Affiliation Departments of Molecular Virology, Immunology, and Medical Genetics and Internal Medicine, Ohio State University, Columbus, Ohio, United States of America

Marco Montagna

Affiliation Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto, IRCCS, Padua, Italy

Emma D'Andrea

Affiliations Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto, IRCCS, Padua, Italy, Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy

Eitan Friedman

Affiliation The Susan Levy Gertner Oncogenetics Unit, Institute of Genetics, Sheba Medical Center, Tel Hashomer, Israel

Yael Laitman

Affiliation The Susan Levy Gertner Oncogenetics Unit, Institute of Genetics, Sheba Medical Center, Tel Hashomer, Israel

Ake Borg

Affiliation Department of Oncology, Lund University, Lund, Sweden

Mary Beattie

Affiliation Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

Susan J. Ramus

Affiliation Gynaecological Oncology Unit, UCL EGA Institute for Women's Health, University College London, United Kingdom

Susan M. Domchek

Affiliation Department of Oncology, The Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Katherine L. Nathanson

Affiliation Department of Cell and Molecular Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Tim Rebbeck

Affiliation Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Amanda B. Spurdle

Affiliation Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia

Xiaoqing Chen

Affiliation Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia

Helene Holland

Affiliation Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia

kConFab

Affiliation Peter MacCallum Cancer Centre, Melbourne, Australia

Esther M. John

Affiliation Cancer Prevention Institute of California, Fremont, California, United States of America

John L. Hopper

Affiliation Centre for Genetic Epidemiology, University of Melbourne, Melbourne, Australia

Saundra S. Buys

Affiliation Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America

Mary B. Daly

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

Melissa C. Southey

Affiliation Centre for Genetic Epidemiology, University of Melbourne, Melbourne, Australia

Mary Beth Terry

Affiliation Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America

Nadine Tung

Affiliation Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Thomas V. Overeem Hansen

Affiliation Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitalet, Copenhagen, Denmark

Finn C. Nielsen

Affiliation Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitalet, Copenhagen, Denmark

Mark I. Greene

Affiliation Clinical Genetics Branch, National Cancer Institute, Rockville, Maryland, United States of America

Phuong L. Mai

Affiliation Clinical Genetics Branch, National Cancer Institute, Rockville, Maryland, United States of America

Ana Osorio

Affiliation Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain

Mercedes Durán

Affiliation Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain

Raquel Andres

Affiliation Oncology Service, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain

Javier Benítez

Affiliation Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain

Jeffrey N. Weitzel

Affiliation City of Hope Cancer Center, Duarte, California, United States of America

Judy Garber

Affiliation Dana Farber Cancer Institute, Harvard University, Boston, Massachusetts, United States of America

Ute Hamann

Affiliation Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany

Susan Peock

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Margaret Cook

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Clare Oliver

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Debra Frost

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Radka Platte

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

D. Gareth Evans

Affiliation Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

Fiona Lalloo

Affiliation Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

Ros Eeles

Affiliation Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom

Louise Izatt

Affiliation Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom

Lisa Walker

Affiliation Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom

Jacqueline Eason

Affiliation Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

Julian Barwell

Affiliation Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

Andrew K. Godwin

Affiliation Women's Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

Rita K. Schmutzler

Affiliation Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany

Barbara Wappenschmidt

Affiliation Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany

Stefanie Engert

Affiliation Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany

Norbert Arnold

Affiliation Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts University Kiel, Kiel, Germany

Dorothea Gadzicki

Affiliation Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany

Michael Dean

Affiliation Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute – Frederick, Frederick, Maryland, United States of America

Bert Gold

Affiliation Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute – Frederick, Frederick, Maryland, United States of America

Robert J. Klein

Affiliation Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Fergus J. Couch

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

Georgia Chenevix-Trench

Affiliation Peter MacCallum Cancer Centre, Melbourne, Australia

Douglas F. Easton

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Mark J. Daly

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America

Antonis C. Antoniou

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

David M. Altshuler

Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America

Kenneth Offit

offitk@mskcc.org

Affiliation Clinical Genetics Service, Department of Medicine, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MD FJC GCT DFE MJD ACA DMA KO. Performed the experiments: TK TG JV JMK CG AVS LM CK JM SH OMS DSL SM MGV HS ML MF GEMO Study Collaborators FBLH MAR JMC NH KEPvR HEBON Study Collaborators MP WR SN LVL SVB TC MdlH HN KA CL IB AA OTJ RBB PD OIO SLN XW ZSF PP SM MB AV PR CMP SN GR FL AF IA GG HO AET MM ED EF YL AB MB SJR SMD KLN TR ABS XC HH kConFab Collaboration EMJ JLH SSB MBD MCS MBT NT TVOH FCN MG PLM AO MD RA JB JNW JG UH SP MC CO DF RP DGE FL RE LI LW JE JB AKG RKS BW SE NA DG KO. Analyzed the data: MMG TK TG KM BG RJK KO. Contributed reagents/materials/analysis tools: TK JV JMK CG AVS LM CK JM SH OMS DSL SM MGV HS ML MF GEMO Study Collaborators FBLH MAR JMC NH KEPvR HEBON Study Collaborators MP WR SN LVL SVB TC MdlH HN KA CL IB AA OTJ RBB PD OIO SLN XW ZSF PP SM MB AV PR CMP SN GR FL AF IA GG HO AET MM ED EF YL AB MB SJR SMD KLN TR ABS XC HH kConFab Collaboration EMJ JLH SSB MBD MCS MBT NT TVOH FCN MG PLM AO MD RA JB JNW JG UH SP MC CO DF RP DGE FL RE LI LW JE JB AKG RKS BW SE NA DG MD BG RJK FJC GCT DFE MJD ACA DMA KO. Wrote the paper: MMG TG JV JMK KM KO.