About the Authors
- Mia M. Gaudet
-
Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn
Affiliation Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York, United States of America
- Tomas Kirchhoff
-
Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn
Affiliations Clinical Genetics Service, Department of Medicine, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
- Todd Green
-
Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn
Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America
- Joseph Vijai
-
Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn
Affiliation Clinical Genetics Service, Department of Medicine, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
- Joshua M. Korn
-
Contributed equally to this work with: Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn
Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America
- Candace Guiducci
-
Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America
- Ayellet V. Segrè
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Affiliations Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
- Kate McGee
-
Affiliation Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute – Frederick, Frederick, Maryland, United States of America
- Lesley McGuffog
-
Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Christiana Kartsonaki
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Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Jonathan Morrison
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Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Sue Healey
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Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Olga M. Sinilnikova
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Affiliations Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard, Lyon, France, Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France
- Dominique Stoppa-Lyonnet
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Affiliations Institut Curie, Service de Génétique, INSERM U830, F-75248, Université Paris Descartes, Paris, France, Service de Genetique Oncologique, Institut Curie, Paris, France
- Sylvie Mazoyer
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Affiliation Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France
- Marion Gauthier-Villars
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Affiliation Service de Genetique Oncologique, Institut Curie, Paris, France
- Hagay Sobol
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Affiliation Département Oncologie génétique, Prévention et Dépistage, INSERM CIC-P9502, Institut Paoli-Calmettes/Université d'Aix-Marseille II, Marseille, France
- Michel Longy
-
Affiliation Institut Bergonié, Bordeaux, France
- Marc Frenay
-
Affiliation Centre Antoine Lacassagne, Nice, France
- GEMO Study Collaborators
-
¶Membership of each consortium is provided in the Acknowledgements.
Affiliation GEMO Study - Cancer Genetics Network “Groupe Génétique et Cancer”, Fédération Nationale des Centres de Lutte Contre le Cancer, Paris, France
- Frans B. L. Hogervorst
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Affiliation Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands
- Matti A. Rookus
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Affiliation Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands
- J. Margriet Collée
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Affiliation Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands
- Nicoline Hoogerbrugge
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Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
- Kees E. P. van Roozendaal
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Affiliation Department of Clinical Genetics, University Medical Center, Maastricht, The Netherlands
- HEBON Study Collaborators
-
¶Membership of each consortium is provided in the Acknowledgements.
Affiliation Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands
- Marion Piedmonte
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Affiliation Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America
- Wendy Rubinstein
-
Affiliation NorthShore University Health System, Evanston, Illinois, United States of America
- Stacy Nerenstone
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Affiliation Central Connecticut Cancer Consortium, Hartford Hospital, Hartford, Connecticut, United States of America
- Linda Van Le
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Affiliation University of North Carolina, Chapel Hill, North Carolina, United States of America
- Stephanie V. Blank
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Affiliation New York University School of Medicine, New York, New York, United States of America
- Trinidad Caldés
-
Affiliation Molecular Oncology Laboratory, Hospital Clinico San Carlos, Madrid, Spain
- Miguel de la Hoya
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Affiliation Molecular Oncology Laboratory, Hospital Clinico San Carlos, Madrid, Spain
- Heli Nevanlinna
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Affiliation Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
- Kristiina Aittomäki
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Affiliation Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland
- Conxi Lazaro
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Affiliation Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain
- Ignacio Blanco
-
Affiliation Hereditary Cancer Program, Catalan Institute of Oncology, Barcelona, Spain
- Adalgeir Arason
-
Affiliations Department of Oncology, Landspitali–LSH, Reykjavik, Iceland, Department of Pathology, Landspitali–LSH, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
- Oskar T. Johannsson
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Affiliations Department of Oncology, Landspitali–LSH, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
- Rosa B. Barkardottir
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Affiliations Department of Oncology, Landspitali–LSH, Reykjavik, Iceland, Department of Pathology, Landspitali–LSH, Reykjavik, Iceland, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
- Peter Devilee
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Affiliation Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
- Olofunmilayo I. Olopade
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Affiliation Center for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, United States of America
- Susan L. Neuhausen
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Affiliation Department of Population Sciences, the Beckman Research Institute of the City of Hope, Duarte, California, United States of America
- Xianshu Wang
-
Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
- Zachary S. Fredericksen
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Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
- Paolo Peterlongo
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Affiliations Unit of Genetic Susceptibility to Cancer, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
- Siranoush Manoukian
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Affiliation Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
- Monica Barile
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Affiliation Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy
- Alessandra Viel
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Affiliation Division of Experimental Oncology 1, Centro di Riferimento Oncologico (CRO), IRCCS, Aviano (PN), Italy
- Paolo Radice
-
Affiliation IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
- Catherine M. Phelan
-
Affiliation Moffitt Cancer Center, Tampa, Florida, United States of America
- Steven Narod
-
Affiliation Women's College Research Institute, Toronto, Canada
- Gad Rennert
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Affiliation CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel
- Flavio Lejbkowicz
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Affiliation CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel
- Anath Flugelman
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Affiliation CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel
- Irene L. Andrulis
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Affiliations Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Cancer Care Ontario, Ontario Cancer Genetics Network, University of Toronto, Toronto, Canada
- Gord Glendon
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Affiliation Cancer Care Ontario, Ontario Cancer Genetics Network, University of Toronto, Toronto, Canada
- Hilmi Ozcelik
-
Affiliations Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, Cancer Care Ontario, Ontario Cancer Genetics Network, University of Toronto, Toronto, Canada
- OCGN
-
¶Membership of each consortium is provided in the Acknowledgements.
Affiliation Cancer Care Ontario, Ontario Cancer Genetics Network, University of Toronto, Toronto, Canada
- Amanda E. Toland
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Affiliation Departments of Molecular Virology, Immunology, and Medical Genetics and Internal Medicine, Ohio State University, Columbus, Ohio, United States of America
- Marco Montagna
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Affiliation Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto, IRCCS, Padua, Italy
- Emma D'Andrea
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Affiliations Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto, IRCCS, Padua, Italy, Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
- Eitan Friedman
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Affiliation The Susan Levy Gertner Oncogenetics Unit, Institute of Genetics, Sheba Medical Center, Tel Hashomer, Israel
- Yael Laitman
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Affiliation The Susan Levy Gertner Oncogenetics Unit, Institute of Genetics, Sheba Medical Center, Tel Hashomer, Israel
- Ake Borg
-
Affiliation Department of Oncology, Lund University, Lund, Sweden
- Mary Beattie
-
Affiliation Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
- Susan J. Ramus
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Affiliation Gynaecological Oncology Unit, UCL EGA Institute for Women's Health, University College London, United Kingdom
- Susan M. Domchek
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Affiliation Department of Oncology, The Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
- Katherine L. Nathanson
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Affiliation Department of Cell and Molecular Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
- Tim Rebbeck
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Affiliation Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
- Amanda B. Spurdle
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Affiliation Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia
- Xiaoqing Chen
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Affiliation Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia
- Helene Holland
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Affiliation Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Australia
- kConFab
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Affiliation Peter MacCallum Cancer Centre, Melbourne, Australia
- Esther M. John
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Affiliation Cancer Prevention Institute of California, Fremont, California, United States of America
- John L. Hopper
-
Affiliation Centre for Genetic Epidemiology, University of Melbourne, Melbourne, Australia
- Saundra S. Buys
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Affiliation Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
- Mary B. Daly
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Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
- Melissa C. Southey
-
Affiliation Centre for Genetic Epidemiology, University of Melbourne, Melbourne, Australia
- Mary Beth Terry
-
Affiliation Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America
- Nadine Tung
-
Affiliation Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
- Thomas V. Overeem Hansen
-
Affiliation Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitalet, Copenhagen, Denmark
- Finn C. Nielsen
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Affiliation Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospitalet, Copenhagen, Denmark
- Mark I. Greene
-
Affiliation Clinical Genetics Branch, National Cancer Institute, Rockville, Maryland, United States of America
- Phuong L. Mai
-
Affiliation Clinical Genetics Branch, National Cancer Institute, Rockville, Maryland, United States of America
- Ana Osorio
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Affiliation Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain
- Mercedes Durán
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Affiliation Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain
- Raquel Andres
-
Affiliation Oncology Service, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
- Javier Benítez
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Affiliation Human Genetics Group and Genotyping Unit, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain
- Jeffrey N. Weitzel
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Affiliation City of Hope Cancer Center, Duarte, California, United States of America
- Judy Garber
-
Affiliation Dana Farber Cancer Institute, Harvard University, Boston, Massachusetts, United States of America
- Ute Hamann
-
Affiliation Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
- Susan Peock
-
Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Margaret Cook
-
Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Clare Oliver
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Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Debra Frost
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Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Radka Platte
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Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- D. Gareth Evans
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Affiliation Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
- Fiona Lalloo
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Affiliation Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
- Ros Eeles
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Affiliation Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom
- Louise Izatt
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Affiliation Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
- Lisa Walker
-
Affiliation Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom
- Jacqueline Eason
-
Affiliation Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
- Julian Barwell
-
Affiliation Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
- Andrew K. Godwin
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Affiliation Women's Cancer Program, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
- Rita K. Schmutzler
-
Affiliation Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany
- Barbara Wappenschmidt
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Affiliation Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany
- Stefanie Engert
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Affiliation Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
- Norbert Arnold
-
Affiliation Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts University Kiel, Kiel, Germany
- Dorothea Gadzicki
-
Affiliation Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
- Michael Dean
-
Affiliation Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute – Frederick, Frederick, Maryland, United States of America
- Bert Gold
-
Affiliation Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute – Frederick, Frederick, Maryland, United States of America
- Robert J. Klein
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Affiliation Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
- Fergus J. Couch
-
Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
- Georgia Chenevix-Trench
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Affiliation Peter MacCallum Cancer Centre, Melbourne, Australia
- Douglas F. Easton
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Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- Mark J. Daly
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Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America
- Antonis C. Antoniou
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Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
- David M. Altshuler
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Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Harvard Medical School, Boston, Massachusetts, United States of America
- Kenneth Offit
-
* E-mail: offitk@mskcc.org
Affiliation Clinical Genetics Service, Department of Medicine, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: MD FJC GCT DFE MJD ACA DMA KO. Performed the experiments: TK TG JV JMK CG AVS LM CK JM SH OMS DSL SM MGV HS ML MF GEMO Study Collaborators FBLH MAR JMC NH KEPvR HEBON Study Collaborators MP WR SN LVL SVB TC MdlH HN KA CL IB AA OTJ RBB PD OIO SLN XW ZSF PP SM MB AV PR CMP SN GR FL AF IA GG HO AET MM ED EF YL AB MB SJR SMD KLN TR ABS XC HH kConFab Collaboration EMJ JLH SSB MBD MCS MBT NT TVOH FCN MG PLM AO MD RA JB JNW JG UH SP MC CO DF RP DGE FL RE LI LW JE JB AKG RKS BW SE NA DG KO. Analyzed the data: MMG TK TG KM BG RJK KO. Contributed reagents/materials/analysis tools: TK JV JMK CG AVS LM CK JM SH OMS DSL SM MGV HS ML MF GEMO Study Collaborators FBLH MAR JMC NH KEPvR HEBON Study Collaborators MP WR SN LVL SVB TC MdlH HN KA CL IB AA OTJ RBB PD OIO SLN XW ZSF PP SM MB AV PR CMP SN GR FL AF IA GG HO AET MM ED EF YL AB MB SJR SMD KLN TR ABS XC HH kConFab Collaboration EMJ JLH SSB MBD MCS MBT NT TVOH FCN MG PLM AO MD RA JB JNW JG UH SP MC CO DF RP DGE FL RE LI LW JE JB AKG RKS BW SE NA DG MD BG RJK FJC GCT DFE MJD ACA DMA KO. Wrote the paper: MMG TG JV JMK KM KO.