About the Authors

Carmen Argmann

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, Illkirch, France

Radu Dobrin

Contributed equally to this work with: Radu Dobrin, Sami Heikkinen

Current address: Merck & Co., Rahway, New Jersey, United States of America

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Sami Heikkinen

Contributed equally to this work with: Radu Dobrin, Sami Heikkinen

Current address: Department of Biosciences, University of Kuopio, Kuopio, Finland

Affiliations Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, Illkirch, France, A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland

Aurélie Auburtin

Affiliation Institut Clinique de la Souris, Illkirch, France

Laurent Pouilly

Affiliation Institut Clinique de la Souris, Illkirch, France

Terrie-Anne Cock

Affiliation Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, Illkirch, France

Hana Koutnikova

Affiliation Institut Clinique de la Souris, Illkirch, France

Jun Zhu

Current address: Sage Bionetwork, Seattle, Washington, United States of America

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Eric E. Schadt

Current address: Pacific Biosciences, Menlo Park, California, United States of America

Affiliation Rosetta Inpharmatics, Seattle, Washington, United States of America

Johan Auwerx

admin.auwerx@epfl.ch

Affiliations Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, Illkirch, France, Institut Clinique de la Souris, Illkirch, France, Ecole polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Competing Interests

RD, JZ, and EES work for Merck and Co. and own stock in the company.

Author Contributions

Conceived and designed the experiments: CA SH TAC EES JA. Performed the experiments: CA RD SH AA LP TAC HK. Analyzed the data: CA RD SH. Contributed reagents/materials/analysis tools: HK JZ EES JA. Wrote the paper: CA RD SH EES JA.