About the Authors

Lan Lin

Affiliation Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

Shihao Shen

Affiliation Department of Biostatistics, University of Iowa, Iowa City, Iowa, United States of America

Anne Tye

Affiliation Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

James J. Cai

Affiliation Department of Biology, Stanford University, Stanford, California, United States of America

Peng Jiang

Affiliation Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

Beverly L. Davidson

Affiliations Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, United States of America, Department of Neurology, University of Iowa, Iowa City, Iowa, United States of America

Yi Xing

yi-xing@uiowa.edu

Affiliations Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LL YX. Performed the experiments: LL SS AT JJC PJ YX. Analyzed the data: LL SS JJC YX. Contributed reagents/materials/analysis tools: SS JJC BLD YX. Wrote the paper: LL YX.