Incompatibilities Involving Yeast Mismatch Repair Genes: A Role for Genetic Modifiers and Implications for Disease Penetrance and Variation in Genomic Mutation Rates

Ann Demogines; Alex Wong; Charles Aquadro; Eric Alani

doi:10.1371/journal.pgen.1000103

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Peer-reviewed

Research Article

Incompatibilities Involving Yeast Mismatch Repair Genes: A Role for Genetic Modifiers and Implications for Disease Penetrance and Variation in Genomic Mutation Rates

Ann Demogines,

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
⨯
Alex Wong,

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
⨯
Charles Aquadro,

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
⨯
Eric Alani

* E-mail: eea3@cornell.edu

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
⨯

Incompatibilities Involving Yeast Mismatch Repair Genes: A Role for Genetic Modifiers and Implications for Disease Penetrance and Variation in Genomic Mutation Rates

Ann Demogines,
Alex Wong,
Charles Aquadro,
Eric Alani

Published: June 20, 2008
https://doi.org/10.1371/journal.pgen.1000103

About the Authors

Ann Demogines

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Alex Wong

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Charles Aquadro

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Eric Alani

* E-mail: eea3@cornell.edu

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AD AW CA EA. Performed the experiments: AD AW EA. Analyzed the data: AD AW CA EA. Wrote the paper: AD AW CA EA.

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Saccharomyces cerevisiae
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Yeast
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Mutation
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Carcinogenesis
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Genetics of disease
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Genomics
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Alleles
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Mismatch repair
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