About the Authors

Kimberly E. Taylor

Affiliation Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

Elaine F. Remmers

Affiliation National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, United States of America

Annette T. Lee

Affiliation Feinstein Institute for Medical Research, North Shore L.I.J. Health System, Manhasset, New York, United States of America

Ward A. Ortmann

Affiliation Genentech, Inc., South San Francisco, California, United States of America

Robert M. Plenge

Affiliations Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America

Chao Tian

Affiliation University of California Davis, Davis, California, United States of America

Sharon A. Chung

Affiliation Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

Joanne Nititham

Affiliation Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

Geoffrey Hom

Affiliation Genentech, Inc., South San Francisco, California, United States of America

Amy H. Kao

Affiliation University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

F. Yesim Demirci

Affiliation University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

M. Ilyas Kamboh

Affiliation University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Michelle Petri

Affiliation Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Susan Manzi

Affiliation University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Daniel L. Kastner

Affiliation National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, United States of America

Michael F. Seldin

Affiliation University of California Davis, Davis, California, United States of America

Peter K. Gregersen

Affiliation Feinstein Institute for Medical Research, North Shore L.I.J. Health System, Manhasset, New York, United States of America

Timothy W. Behrens

Affiliation Genentech, Inc., South San Francisco, California, United States of America

Lindsey A. Criswell

lindsey.criswell@ucsf.edu

Affiliation Rosalind Russell Medical Research Center for Arthritis, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

R. Plenge reports receiving consulting fees from Biogen-Idec and lecture fees from Genentech. P. Gregersen reports receiving honoraria from Biogen Idec, Genentech, and Roche Pharmaceuticals. L. Criswell has received consulting fees from Celera Diagnostics. Authors T. Behrens, W. Ortmann, and G. Hom are employees of Genentech, Inc.

Author Contributions

Conceived and designed the experiments: PG TB LC. Analyzed the data: KT RP CT GH MS LC. Wrote the paper: KT LC. Performed genotyping: ER AL DK PG. Managed data collaboration: WO. Reviewed and normalized clinical data: SC JN FD MK MP SM. Contributed subjects and clinical data: AK FD MK MP SM PG TB LC.