About the Authors
- David Melzer
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Contributed equally to this work with: David Melzer, John R. B. Perry, Dena Hernandez
Affiliations Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom, Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- John R. B. Perry
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Contributed equally to this work with: David Melzer, John R. B. Perry, Dena Hernandez
Affiliation Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- Dena Hernandez
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Contributed equally to this work with: David Melzer, John R. B. Perry, Dena Hernandez
Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Anna-Maria Corsi
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Affiliation Tuscany Regional Health Agency, I.O.T. and Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
- Kara Stevens
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Affiliations Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom, Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- Ian Rafferty
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Fulvio Lauretani
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Affiliation Tuscany Regional Health Agency, I.O.T. and Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
- Anna Murray
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Affiliations Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom, Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- J. Raphael Gibbs
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Giuseppe Paolisso
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Affiliation Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy
- Sajjad Rafiq
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Affiliations Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom, Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- Javier Simon-Sanchez
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Hana Lango
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Affiliation Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- Sonja Scholz
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Michael N. Weedon
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Affiliation Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- Sampath Arepalli
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Neil Rice
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Affiliations Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom, Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- Nicole Washecka
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Alison Hurst
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Affiliations Department of Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom, Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- Angela Britton
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- William Henley
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Affiliation School of Mathematics and Statistics, University of Plymouth, Plymouth, United Kingdom
- Joyce van de Leemput
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Rongling Li
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Affiliation Department of Preventive Medicine and Center for Genomics and Bioinformatics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
- Anne B. Newman
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Affiliation University of Pittsburgh, Graduate School of Public Health, Departments of Epidemiology and Medicine, Pittsburgh, Pennsylvania, United States of America
- Greg Tranah
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Affiliation San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, United States of America
- Tamara Harris
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Affiliation Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, United States of America
- Vijay Panicker
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Affiliations Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom, Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Bristol, United Kingdom
- Colin Dayan
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Affiliation Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Bristol, United Kingdom
- Amanda Bennett
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Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Headington, Oxford, United Kingdom
- Mark I. McCarthy
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Affiliations Oxford Centre for Diabetes, Endocrinology and Metabolism, Headington, Oxford, United Kingdom, The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, United Kingdom
- Aimo Ruokonen
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Affiliation Department of Clinical Chemistry, University of Oulu, Oulu, Finland
- Marjo-Riitta Jarvelin
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Affiliations Department of Public Health, Science, and General Practice, University of Oulu, Oulu, Finland, Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
- Jack Guralnik
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Affiliation Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, United States of America
- Stefania Bandinelli
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Affiliation Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy
- Timothy M. Frayling
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* E-mail: tim.frayling@pms.ac.uk
Affiliation Genetics of Complex Traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Devon, United Kingdom
- Andrew Singleton
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Affiliation Laboratory of Neurogenetics, National Institute of Aging, Porter Neuroscience Research Center, Bethesda, Maryland, United States of America
- Luigi Ferrucci
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Affiliation Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: D Melzer, J Perry, D Hernandez, T Frayling, A Singleton, L Ferrucci. Performed the experiments: D Hernandez, I Rafferty, J Gibbs, J Simon-Sanchez, S Scholz, S Arepalli, N Washecka, A Britton, J van de Leemput, A Singleton. Analyzed the data: J Perry, K Stevens, A Murray, S Rafiq, H Lango, M Weedon, N Rice, A Hurst, W Hurst, A Singleton. Contributed reagents/materials/analysis tools: A Corsi, F Lauretani, G Paolisso, R Layan, A Newman, G Tranah, T Harris, V Panicker, C D A Bennett, M McCarthy, A Ruokonen, M Järvelin, J Guralnik, S Bandinelli, A Singleton, L Ferrucci. Wrote the paper: D Melzer, J Perry, D Hernandez, T. Frayling, L Ferrucci.