The Role of Mitochondrial DNA Mutations in Mammalian Aging

Gregory C Kujoth; Patrick C Bradshaw; Suraiya Haroon; Tomas A Prolla

doi:10.1371/journal.pgen.0030024

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The Role of Mitochondrial DNA Mutations in Mammalian Aging

Gregory C Kujoth,
Patrick C Bradshaw,
Suraiya Haroon,
Tomas A Prolla

*To whom correspondence should be addressed. E-mail: taprolla@wisc.edu.
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The Role of Mitochondrial DNA Mutations in Mammalian Aging

Gregory C Kujoth,
Patrick C Bradshaw,
Suraiya Haroon,
Tomas A Prolla

Published: February 23, 2007
https://doi.org/10.1371/journal.pgen.0030024

About the Authors

Gregory C Kujoth
Patrick C Bradshaw
Suraiya Haroon
Tomas A Prolla: *To whom correspondence should be addressed. E-mail: taprolla@wisc.edu.

Competing Interests

GCK and TAP were awarded a United States patent (7,126,040) for the PolgD257A mouse model described here. TAP is a partial owner and scientific consultant for LifeGen Technologies, specializing in the application of DNA microarray analysis to analyzing nutraceutical interventions in aging.

Author Contributions

GCK, PCB, SH, and TAP wrote the paper.

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Mitochondrial DNA
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Mitochondria
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Mouse models
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Deletion mutation
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Apoptosis
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Aging
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Frameshift mutation
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Heart
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