About the Authors

Noah A Rosenberg

To whom correspondence should be addressed. E-mail: rnoah@umich.edu (NAR); pragna@usc.edu (PIP)

Affiliation Department of Human Genetics, Bioinformatics Program, and the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

Saurabh Mahajan

Affiliation Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Catalina Gonzalez-Quevedo

Affiliation Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Michael G. B Blum

Affiliation Department of Human Genetics, Bioinformatics Program, and the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America

Laura Nino-Rosales

Affiliation Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America

Vasiliki Ninis

Affiliation Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America

Parimal Das

Affiliation Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America

Madhuri Hegde

¤ Current address: Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Laura Molinari

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Gladys Zapata

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

James L Weber

Affiliation Center for Medical Genetics, Marshfield Medical Research Foundation, Marshfield, Wisconsin, United States of America

John W Belmont

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Pragna I Patel

To whom correspondence should be addressed. E-mail: rnoah@umich.edu (NAR); pragna@usc.edu (PIP)

Affiliations Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America , Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

NAR and PIP conceived and designed the study. PIP, JWB, CGQ, LNR, PD, VN, MH, and GZ collected the samples. LNR prepared the DNA. CGQ, LM, and GZ created immortalized B-cell lines, under the supervision of JWB and PIP. JLW supervised the genotyping. NAR, SM, and MGBB analyzed the data. NAR and PIP wrote the paper.