About the Authors

John T Johnson

Contributed equally to this work with: John T Johnson, Mark S Hansen

Affiliation Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States of America

Mark S Hansen

Contributed equally to this work with: John T Johnson, Mark S Hansen

Affiliation Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America

Isabel Wu

Affiliation Department of Cellular & Structural Biology and Department of Pediatrics, Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas, United States of America

Lindsey J Healy

Affiliation Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States of America

Christopher R Johnson

Affiliation Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States of America

Greg M Jones

Affiliation Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States of America

Mario R Capecchi

Affiliations Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America , Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, United States of America

Charles Keller

To whom correspondence should be addressed. E-mail: kellerc2@uthscsa.edu

Affiliation Department of Cellular & Structural Biology and Department of Pediatrics, Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas, United States of America

Competing Interests

CK is the co-founder of a biotechnology company named Numira Biosciences, which may pursue the commercialization of the patent-pending technology in this manuscript. The intent of our manuscript, however, is to communicate this method so that it may be reproduced and utilized freely at academic institutions.

Author Contributions

CK conceived and designed the experiments. MSH, IW, and CK performed the experiments. JTJ, LJH, GMJ, MRC, and CK analyzed the data. CRJ and GMJ contributed reagents/materials/analysis tools. JTJ and CK wrote the paper.