About the Authors

Adam R. Boyko

Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Scott H. Williamson

Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

Amit R. Indap

Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

Jeremiah D. Degenhardt

Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

Ryan D. Hernandez

Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

Kirk E. Lohmueller

Affiliations Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Mark D. Adams

Affiliation Department of Genetics, BRB-624, Case Western Reserve University, Cleveland, Ohio, United States of America

Steffen Schmidt

Affiliation Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

John J. Sninsky

Affiliation Celera Diagnostics, Alameda, California, United States of America

Shamil R. Sunyaev

Affiliation Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Thomas J. White

Affiliation Celera Diagnostics, Alameda, California, United States of America

Rasmus Nielsen

Affiliation Center for Comparative Genomics, University of Copenhagen, Copenhagen, Denmark

Andrew G. Clark

Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

Carlos D. Bustamante

cdb28@cornell.edu

Affiliation Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB SW MA JS TW RN AC. Performed the experiments: AB AI JD RH KL MA. Analyzed the data: AB AI JD RH KL SS. Contributed reagents/materials/analysis tools: AB SW AI RH SS RN. Wrote the paper: AB RN AC.