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Pancreatic cancer  
PLOS Computational Biology  
Integrative pan-cancer analysis reveals a common architecture of dysregulated transcriptional networks characterized by loss of enhancer methylation

Jørgen Ankill, Zhi Zhao, Xavier Tekpli, Elin H. Kure, Vessela N. Kristensen, Anthony Mathelier, Thomas Fleischer

Research Article | published 18 Nov 2024 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1012565

Views: 535Citations: 0Saves: 0 • Shares: 0

Identification of a serum proteomic biomarker panel using diagnosis specific ensemble learning and symptoms for early pancreatic cancer detection

Alexander Ney, Nuno R. Nené, Eva Sedlak, Pilar Acedo, Oleg Blyuss, Harry J. Whitwell, Eithne Costello, Aleksandra Gentry-Maharaj, Norman R. Williams, Usha Menon, Giuseppe K. Fusai, Alexey Zaikin, Stephen P. Pereira

Research Article | published 29 Aug 2024 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1012408

Views: 931Citations: 0Saves: 29 • Shares: 1

Kernel Bayesian logistic tensor decomposition with automatic rank determination for predicting multiple types of miRNA-disease associations

Yingjun Ma, Yuanyuan Ma

Research Article | published 08 Jul 2024 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1012287

Views: 662Citations: 0Saves: 0 • Shares: 0

An integrated model for predicting KRAS dependency

Yihsuan S. Tsai, Yogitha S. Chareddy, Brandon A. Price, Joel S. Parker, Chad V. Pecot

Research Article | published 04 May 2023 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1011095

Views: 3354Citations: 2Saves: 14 • Shares: 17

Examining the efficacy of localised gemcitabine therapy for the treatment of pancreatic cancer using a hybrid agent-based model

Adrianne L. Jenner, Wayne Kelly, Michael Dallaston, Robyn Araujo, Isobelle Parfitt, Dominic Steinitz, Pantea Pooladvand, Peter S. Kim, Samantha J. Wade, Kara L. Vine

Research Article | published 17 Jan 2023 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1010104

Views: 2302Citations: 4Saves: 24 • Shares: 0

ToMExO: A probabilistic tree-structured model for cancer progression

Mohammadreza Mohaghegh Neyshabouri, Jens Lagergren

Research Article | published 05 Dec 2022 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1010732

Views: 1402Citations: 2Saves: 10 • Shares: 1

DSCN: Double-target selection guided by CRISPR screening and network

Enze Liu, Xue Wu, Lei Wang, Yang Huo, Huanmei Wu, Lang Li, Lijun Cheng

Research Article | published 19 Aug 2022 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1009421

Views: 1963Citations: 1Saves: 16 • Shares: 4

Designing optimal allocations for cancer screening using queuing network models

Justin Dean, Evan Goldberg, Franziska Michor

Research Article | published 27 May 2022 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1010179

Views: 1604Citations: 2Saves: 3 • Shares: 5

Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors

Mansour Poorebrahim, Mohammad Foad Abazari, Leila Moradi, Behzad Shahbazi, Reza Mahmoudi, Hourieh Kalhor, Hassan Askari, Ladan Teimoori-Toolabi

Research Article | published 26 Apr 2022 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1009962

Views: 3046Citations: 3Saves: 22 • Shares: 3

AIME: Autoencoder-based integrative multi-omics data embedding that allows for confounder adjustments

Tianwei Yu

Research Article | published 26 Jan 2022 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1009826

Views: 4545Citations: 22Saves: 32 • Shares: 3

Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts

Kaiyi Zhu, Lingyi Cai, Chenqian Cui, Juan R. de los Toyos, Dimitris Anastassiou

Research Article | published 20 Jul 2021 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1009228

Views: 6601Citations: 44Saves: 48 • Shares: 11

De novo mutational signature discovery in tumor genomes using SparseSignatures

Avantika Lal, Keli Liu, Robert Tibshirani, Arend Sidow, Daniele Ramazzotti

Research Article | published 28 Jun 2021 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1009119

Views: 4620Citations: 28Saves: 57 • Shares: 21

Comprehensive analysis of cancer breakpoints reveals signatures of genetic and epigenetic contribution to cancer genome rearrangements

Kseniia Cheloshkina, Maria Poptsova

Research Article | published 01 Mar 2021 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1008749

Views: 3536Citations: 14Saves: 29 • Shares: 8

A mathematical model of the metastatic bottleneck predicts patient outcome and response to cancer treatment

Ewa Szczurek, Tyll Krüger, Barbara Klink, Niko Beerenwinkel

Research Article | published 02 Oct 2020 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1008056

Views: 4008Citations: 21Saves: 33 • Shares: 22

SourceSet: A graphical model approach to identify primary genes in perturbed biological pathways

Elisa Salviato, Vera Djordjilović, Monica Chiogna, Chiara Romualdi

Research Article | published 25 Oct 2019 PLOS Computational Biology

https://doi.org/10.1371/journal.pcbi.1007357

Views: 4047Citations: 4Saves: 33 • Shares: 10

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