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PLoS Computational Biology Issue Image | Vol. 17(1) February 2021

PLoS Computational Biology Issue Image | Vol. 17(1) February 2021

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Mapping of soft disorder residues and interface regions in alternative crystals of p53

The DNA binding domain of protein p53 is found complexed with many other proteins and DNA in the Protein Data Bank (PDB). The outer wheel shows soft disordered (in orange) and interface (in blue) regions observed in alternative crystals of these complexes. In the center, we show that once mapped on the structure, the union of all soft disordered regions and the union of all the interface regions tend to involve the same amino acids in the protein.

Image Credit: Beatriz Seoane

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Mapping of soft disorder residues and interface regions in alternative crystals of p53

The DNA binding domain of protein p53 is found complexed with many other proteins and DNA in the Protein Data Bank (PDB). The outer wheel shows soft disordered (in orange) and interface (in blue) regions observed in alternative crystals of these complexes. In the center, we show that once mapped on the structure, the union of all soft disordered regions and the union of all the interface regions tend to involve the same amino acids in the protein.

Image Credit: Beatriz Seoane

https://doi.org/10.1371/image.pcbi.v17.i01.g001